Name: BrCH2CONH-PEG3-COOtBu
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]propanoate

Synonyms

Bromoacetamido-PEG3-t-butyl ester; Bromoacetamido-PEG3-C2-Boc; tert-butyl 1-bromo-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate; 4,7,10-Trioxa-13-azapentadecanoic acid, 15-bromo-14-oxo-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl 1-bromo-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate; 6,9,12-Trioxa-3-azapentadecan-15-oic acid, 1-bromo-2-oxo-, 1,1-dimethylethyl ester

Boiling Point

507.6±50.0°C at 760 mmHg

Density

1.3±0.1 g/cm3

InChI Key

QAQLZWBWKHLATI-UHFFFAOYSA-N

InChI

InChI=1S/C15H28BrNO6/c1-15(2,3)23-14(19)4-6-20-8-10-22-11-9-21-7-5-17-13(18)12-16/h4-12H2,1-3H3,(H,17,18)

SMILES

CC(C)(C)OC(=O)CCOCCOCCOCCNC(=O)CBr

BrCH2CONH-PEG3-COOtBu, is designed to support efficient PROTAC assembly by providing a flexible hydrophilic spacer and a functional handle for conjugation to ligands. Its ether-rich chain improves solubility and conformational adaptability, which can enhance productive ternary complex formation. The protected carboxylate enables controlled downstream coupling, while the bromoacetamide motif offers a practical electrophilic site for stepwise construction.

Structure: The linker contains an ether-rich PEG segment that imparts flexibility and hydrophilicity, flanked by a bromoacetamide unit and a tert-butyl-protected carboxylate. It features amide and ether linkages, an alkyl bromide electrophile, and a protected ester functionality that can be selectively unmasked for coupling.

Reactivity: The bromoacetamide portion can participate in nucleophilic substitution reactions with amine or other nucleophiles under standard organic synthesis conditions, enabling ligand attachment. The tert-butyl ester is typically removed under acid-mediated deprotection to reveal a carboxylic acid for amide or related bond formation. Common coupling strategies employ activated carboxylic acid derivatives with appropriate bases and dry, inert solvents, using established peptide-coupling chemistries.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂