DBCO-PEG10-DBCO
Cat No.: BP-501844
4.5 
DBCO-PEG10-DBCO is a bifunctional polyethylene glycol (PEG) linker bearing two strained cyclooctyne (DBCO) groups at the termini, separated by a PEG chain of intermediate length that provides aqueous solubility and flexibility. Structurally, it enables copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) to efficiently conjugate two azide-functional partners in a single step, forming stable triazole linkages without the need for cytotoxic copper catalysts. In PROTAC and targeted degradation workflows, this linker is particularly useful for modular assembly of heterobifunctional constructs, allowing researchers to connect an E3 ligase ligand and a target-binding moiety (or other functional handles) through orthogonal, high-yield click chemistry while minimizing steric constraints through the PEG spacer. Its PEG-based spacer and dual DBCO reactivity make it valuable for optimizing linker length, maintaining binding accessibility, and generating reproducible conjugates for mechanistic studies and degradation efficacy screening.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This DBCO-PEG10-DBCO linker is a bifunctional, strain-promoted cyclooctyne (DBCO)–PEG conjugate designed for efficient assembly of PROTACs and related targeted degradation constructs. It enables rapid, bioorthogonal conjugation through copper-free click chemistry, offering high coupling efficiency and compatibility with sensitive biomolecule-binding ligands. Its PEG spacer improves solubility and can help tune effective linker length and flexibility. Detailed structural and reactivity considerations are provided below.
Structure: The molecule contains two DBCO groups connected by a poly(ethylene glycol) chain, providing a flexible, hydrophilic spacer between strained cyclooctyne moieties. It features ether linkages within the PEG segment and strained alkyne functionality suited for cycloaddition chemistry. Overall, it is designed to be soluble and conjugation-ready.
Reactivity: DBCO groups typically undergo strain-promoted azide–alkyne cycloaddition with azide-bearing partners under copper-free conditions. For PROTAC assembly, this linker is commonly used to connect azide-functional warheads or recruiting ligands to complementary azide/alkyne handles, forming stable triazole linkages. Reactions are generally performed in polar organic or aqueous buffer systems compatible with the azide substrate, with mild temperatures and no copper catalyst required.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
