DSPE-PEG46-NH2
Cat No.: BP-501788
4.5 
DSPE-PEG46-NH2 is an amine-terminated phospholipid–poly(ethylene glycol) conjugate built from the hydrophobic DSPE anchor linked to a long PEG chain, providing a stable, flexible spacer between a lipid domain and a terminal primary amine. In PROTAC and targeted degradation workflows, such PEG linkers are commonly used to engineer solubility, reduce nonspecific interactions, and introduce a chemically accessible handle for conjugation to other PROTAC components or carrier scaffolds. The DSPE moiety can support membrane association or hydrophobic anchoring, while the PEG segment acts as a hydrated, steric barrier that helps maintain functional group availability and improves biocompatible presentation of the conjugation site. The terminal NH2 enables straightforward coupling strategies (e.g., amide or urea formation) to attach targeting ligands, linkers, or degraders, facilitating modular assembly and optimization of degradation constructs. This makes DSPE-PEG46-NH2 a useful reagent for researchers developing well-defined, conjugatable PROTAC architectures and evaluating how linker chemistry influences efficacy and specificity.
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* For research and manufacturing use only. Not for human or clinical use.
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DSPE-PEG46-NH2 is a PEG-based lipid linker designed to support PROTAC assembly by providing a flexible, hydrophilic spacer and a terminal primary amine for controlled conjugation to targeting ligands. Its amphiphilic character can improve solubility and presentation of conjugates in aqueous environments, which is advantageous for constructing multicomponent degraders. The points below describe the molecule’s structure and practical reactivity for PROTAC-relevant synthesis.
Structure: The linker combines a phospholipid (DSPE) hydrophobic domain with an extended polyethylene glycol chain, terminating in a primary amine. It contains ether linkages within the PEG segment and phosphoester functionality in the lipid headgroup, yielding an amphiphilic, water-compatible spacer suitable for bioconjugation.
Reactivity: The terminal amine enables standard amide or urea-forming coupling reactions with activated carboxylic acids or isocyanates under typical bioconjugation conditions. Common approaches use carbodiimide-mediated coupling or related coupling chemistries in polar aprotic or buffered aqueous mixtures, often with base to promote nucleophilic acyl substitution. Reaction design should consider maintaining PEG chain integrity and minimizing side reactions during linker–ligand conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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