Mal-PEG12-alcohol
Cat No.: BP-501761
4.5 
Mal-PEG12-alcohol is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal maleimide group (Mal) and a terminal hydroxyl (alcohol), providing a flexible, water-soluble spacer with a defined PEG chain length. In PROTAC and related targeted protein degradation constructs, the maleimide moiety serves as a highly reactive Michael acceptor that can selectively conjugate to thiol-containing ligands (for example, cysteine residues or engineered thiol tags) under mild aqueous conditions, enabling efficient attachment of the linker to one component while the PEG segment maintains solubility and reduces steric interference. The terminal alcohol can be used for downstream functionalization or coupling strategies, facilitating modular assembly of degradation platforms. This linker is valuable for researchers seeking robust, site-selective conjugation and improved biophysical properties in PROTAC design, particularly when optimizing linker length and flexibility to balance target engagement and ternary complex formation.
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* For research and manufacturing use only. Not for human or clinical use.
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Mal-PEG12-alcohol is a polyethylene glycol (PEG) based linker bearing a maleimide handle and a terminal alcohol, designed to enable efficient conjugation in targeted protein degradation workflows. Its maleimide functionality supports selective coupling to thiol-containing ligands, while the PEG spacer improves solubility and can help tune the effective distance and flexibility between the two binding elements of a PROTAC. The subsequent points describe its structure and practical reactivity considerations in detail below.
Structure: The linker comprises a maleimide moiety connected to a PEG chain terminating in an alcohol. It contains a cyclic imide with an electron-deficient alkene suitable for Michael-type addition, along with multiple ether linkages that confer hydrophilicity and conformational flexibility typical of PEG spacers.
Reactivity: Maleimide groups react with thiols via a Michael addition under mildly basic to neutral aqueous conditions, forming a stable thioether linkage. For PROTAC assembly, thiol-bearing targeting ligands are typically introduced to the maleimide linker in buffered solvent systems compatible with thiol chemistry, while maintaining low levels of competing nucleophiles and avoiding conditions that promote maleimide hydrolysis. No special catalysts are generally required; careful control of pH, temperature, and ligand thiol availability is essential for reproducible coupling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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