Fluorescein-PEG3-amine
CAS No.: 1807539-04-3
Cat No.: BP-501291
Purity: 96%
4.5 
Fluorescein-PEG3-amine is a fluorescein dye conjugated to a short, flexible polyethylene glycol linker terminating in a primary amine. The PEG3 segment provides a hydrophilic, spacer-like chain that reduces steric interference between the dye and the biomolecular partners, while the terminal amine enables straightforward coupling to activated carboxyl groups or NHS-esters, facilitating attachment to PROTAC components or other targeting ligands. In targeted protein degradation workflows, this linker–reporter conjugate is valuable as a fluorescent handle for monitoring synthesis, verifying conjugation efficiency, and tracking cellular uptake or intracellular localization of PROTAC constructs. Its dye properties support sensitive detection by fluorescence microscopy or flow cytometry, allowing researchers to optimize linker length, attachment chemistry, and experimental conditions. Overall, it is a practical tool for studying PROTAC assembly and behavior without significantly altering the core recognition elements when used at appropriate labeling densities.
Structure of 1807539-04-3
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Fluorescein-PEG3-amine is a functionalized PEG-based linker bearing a fluorescein fluorophore and a terminal primary amine, enabling facile conjugation to targeting ligands used in PROTAC design. Its flexible, hydrophilic PEG segment can improve solubility and linker presentation, while the fluorescein tag supports fluorescence-based tracking of synthesis progress and cellular uptake in experimental workflows. The structure and reactivity of this linker are described in detail below to guide PROTAC assembly.
Structure: The molecule combines a fluorescein aromatic core with an ether-rich PEG chain terminating in a primary amine. It contains conjugated ring systems, multiple ether linkages, and a reactive amino group suitable for amide formation. The overall polarity and hydrogen-bonding capacity favor aqueous compatibility.
Reactivity: The terminal primary amine is well suited for coupling reactions that form stable amide or urea linkages with activated carboxylic acids or electrophilic carbonyl derivatives. Typical PROTAC assembly strategies use carbodiimide-mediated amidation or activated ester/acid chloride chemistry under mild base conditions, often in polar aprotic solvents. Fluorescein’s conjugated system generally tolerates standard coupling conditions, supporting downstream analytical confirmation by fluorescence.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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