Fmoc-N-amido-PEG9-acid
CAS No.: 1191064-81-9
Cat No.: BP-500771
Purity: ≥95%
4.5 
Fmoc-N-amido-PEG9-acid is an Fmoc-protected, carboxyl-terminated polyethylene glycol linker featuring an amide linkage and a PEG chain long enough to provide a flexible, hydrophilic spacer between conjugation partners. The Fmoc group enables solid-phase or activated-carboxyl coupling strategies, while the terminal carboxylic acid allows attachment to PROTAC warheads, E3 ligase ligands, or other functional modules through amide-bond formation. In PROTAC design, this type of PEG spacer helps reduce steric interference, improves effective reach between the recruited target-binding ligand and the ligase-binding ligand, and can modulate solubility and local microenvironment around the ternary complex. Researchers use Fmoc-N-amido-PEG9-acid to systematically tune linker length and flexibility, facilitating structure–activity relationship studies and aiding the development of targeted protein degradation constructs with more favorable conjugation geometry.
Structure of 1191064-81-9
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Fmoc-N-amido-PEG9-acid, is designed to provide a hydrophilic polyethylene glycol spacer with an orthogonally protected amine handle and a terminal carboxylic acid for conjugation. Its PEG character supports favorable solubility and reduced nonspecific interactions, while the Fmoc group enables controlled stepwise assembly of PROTAC constructs. The subsequent sections describe the linker’s structural features and practical synthetic considerations for building targeted protein degraders.
Structure: The linker contains an Fmoc-protected amide-bearing nitrogen connected to a polyethylene glycol chain terminating in a carboxylic acid. It features aromatic carbamate functionality, multiple ether linkages within the PEG segment, and stable amide and ester-compatible bond motifs that support flexible, water-compatible spacing.
Reactivity: The terminal carboxylic acid enables amide coupling to lysine or amine-bearing ligands using standard peptide-coupling chemistries under mild base conditions. The Fmoc group can be removed with base to reveal an amine for subsequent coupling steps, supporting sequential PROTAC assembly. Typical reagents include carbodiimide or uronium-type activators with coupling additives in polar aprotic solvents; reaction progress is monitored by chromatography or mass spectrometry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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