Name: Hydroxy-Amino-bis(PEG1-C2-Boc)
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-hydroxyethyl-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethyl]amino]ethoxy]propanoate

InChI Key

OUIZBEKRHPKXAD-UHFFFAOYSA-N

InChI

InChI=1S/C20H39NO7/c1-19(2,3)27-17(23)7-13-25-15-10-21(9-12-22)11-16-26-14-8-18(24)28-20(4,5)6/h22H,7-16H2,1-6H3

SMILES

CC(C)(C)OC(=O)CCOCCN(CCO)CCOCCC(=O)OC(C)(C)C

This branched linker precursor combines a central tertiary amine, a free alcohol, and protected carboxyl arms. It enables branch-point functionalization and later acid unveiling, offering a compact route to multicomponent or topology-focused PROTAC designs. Its structure and reaction behavior are outlined below.

Structure: A tertiary amine core bears a hydroxyethyl substituent and ether-containing arms ending as tert-butyl propanoates. The molecule contains flexible carbon–oxygen and carbon–nitrogen single bonds, ester carbonyls, a free primary alcohol, and a basic tertiary amine branch point.

Reactivity: The alcohol can be converted into an ester, carbonate, carbamate, or ether after activation, using an appropriate acylating agent, chloroformate, or leaving-group-forming reagent with base in an anhydrous solvent. Acidic cleavage of the tert-butyl esters subsequently reveals carboxyl groups for amide coupling. The tertiary amine may bind acid or metal catalysts, so reagent loading and purification should be optimized experimentally.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂