Hydroxy-PEG4-propionic acid

 CAS No.: 937188-59-5  Cat No.: BP-500391  Purity: >98.0% 4.5  

Hydroxy-PEG4-propionic acid is a hydrophilic PEG linker featuring hydroxyl and carboxyl groups, facilitating dual reactivity in ADC linker design. It enables efficient conjugation and improves solubility and stability of antibody-drug conjugates in therapeutic applications.

Hydroxy-PEG4-propionic acid

Structure of 937188-59-5

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Category
PROTAC Linker
Molecular Formula
C11H22O7
Molecular Weight
266.29
Appearance
Pale Yellow or Colorless Oily Matter

* For research and manufacturing use only. Not for human or clinical use.

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Purity
>98.0%
Solubility
Soluble in DMSO
Appearance
Pale Yellow or Colorless Oily Matter
ShelfLife
-20°C 3 years powder; -80°C 2 years in solvent
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature, or blue ice upon request.
IUPACName
3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoic acid
Synonyms
OH-PEG4-COOH; HO-PEG4-Propionic acid; HO-PEG4-CH2CH2COOH; Hydroxy-PEG4-acid; 1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oic acid; 15-Hydroxy-4,7,10,13-tetraoxapentadecanoic Acid; α,ω-hydroxy-propionic acid tetraethylene glycol; 4,7,10,13-Tetraoxapentadecanoic acid, 15-hydroxy-; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-hydroxy-
Boiling Point
420.7±40.0 °C at 760 mmHg
Density
1.169±0.06 g/cm3 (Predicted)
InChI Key
UQWLGZFJGVEDCQ-UHFFFAOYSA-N
InChI
InChI=1S/C11H22O7/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h12H,1-10H2,(H,13,14)
Canonical SMILES
C(COCCOCCOCCOCCO)C(=O)O

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It is commonly abbreviated as: C1V1 = C2V2

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Historical Records: PEG12-Tos | m-PEG24-NHS ester | Fmoc-N-PEG23-acid | m-PEG36-azide | Ms-PEG12-m | Bis-(N,N'-PEG4-NHS ester)-Cy5 | Bromo-PEG4-propionic acid | Bis-CH2-PEG2-acid | Nonaethylene glycol di(p-toluenesulfonate) | Mal-PEG2-oxyamine | Hydroxy-PEG4-propionic acid

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