Name: mPEG3-thiol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>95%

Appearance

Colorless Liquid

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-(2-methoxyethoxy)ethoxy]ethanethiol

Synonyms

mPEG3-SH; 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol

Boiling Point

234.3±25.0 °C at 760 mmHg

Density

1.017 g/mL

InChI Key

DMFFSDWRRLCKKN-UHFFFAOYSA-N

InChI

InChI=1S/C7H16O3S/c1-8-2-3-9-4-5-10-6-7-11/h11H,2-7H2,1H3

SMILES

COCCOCCOCCS

mPEG3-thiol is a methoxy PEG thiol linker for introducing a short polar spacer and a sulfur-based conjugation handle into PROTAC intermediates. Its terminal thiol enables chemoselective thioether formation with appropriate electrophilic partners. Structural and reactivity details are provided below.

Structure: The molecule contains a methoxy-capped oligoethylene glycol chain terminating in a thiol group. Ether bonds provide flexibility and hydrophilicity, while the sulfur-hydrogen terminus acts as a soft nucleophile.

Reactivity: The thiol reacts efficiently with maleimides through Michael addition and with haloalkyl or haloacetamide groups through substitution to form thioether linkages. Mild base or buffered conditions are commonly used to modulate thiolate formation. Oxygen exposure should be limited to suppress disulfide formation during PROTAC linker coupling.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂