Mal-amido-PEG10-acid
Cat No.: BP-501731
4.5 
Mal-amido-PEG10-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide-derived amide functionality and a terminal carboxylic acid, connected through an approximately ten-unit PEG chain. The PEG segment provides aqueous solubility and molecular flexibility, helping to reduce steric constraints between the PROTAC’s binding moieties and improving conjugation efficiency. In targeted protein degradation designs, the maleimide-type electrophile enables chemoselective coupling to thiol-containing partners (for example, cysteine-bearing ligands or engineered protein-binding modules), forming a stable thioether linkage under mild conditions. The terminal carboxylic acid offers a convenient handle for subsequent amide bond formation or other acyl coupling strategies to attach the second functional component, such as an E3 ligase ligand or targeting ligand. This linker is valuable for constructing modular PROTACs and related degraders that require controlled spacing, reliable thiol conjugation, and robust downstream functionalization for experimental optimization.
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* For research and manufacturing use only. Not for human or clinical use.
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Mal-amido-PEG10-acid is a polyethylene glycol-based PROTAC linker featuring a malonamide motif and a terminal carboxylic acid, designed to support efficient conjugation between targeting ligands and E3-recruiting modules. Its flexible, hydrophilic PEG character can help tune linker length, solubility, and overall conformational behavior in targeted protein degradation constructs. The following sections describe the structure and the practical reactivity considerations for building PROTACs using this linker.
Structure: The linker comprises a PEG chain providing conformational flexibility and hydrogen-bonding capability, coupled to an amide-containing segment that supports stable covalent attachment. A terminal carboxylic acid enables formation of activated ester or amide derivatives. Overall, it presents a polar, water-compatible architecture with robust amide bond stability.
Reactivity: The terminal carboxylic acid is typically converted into an activated intermediate (for example, an NHS ester or acid chloride) under standard coupling conditions, then reacted with complementary nucleophiles such as amines on the PROTAC partner. Common approaches use coupling reagents and base in polar aprotic solvents, with temperature control to limit side reactions. Amide-bond formation proceeds via acyl-activation followed by nucleophilic substitution, yielding stable linker conjugates suitable for PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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