Name: Mal-amido-PEG2-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>97%

Appearance

White Solid

Storage

4°C, stored under nitrogen; In solvent, -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]propanoic acid

Synonyms

Mal-amido-PEG2-C2-acid; 3-[2-[2-[[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]propanoic acid

Boiling Point

617.3±55.0 °C at 760 mmHg

Density

1.3±0.1 g/cm3

InChI Key

GBPJQBDDYXDSNH-UHFFFAOYSA-N

InChI

InChI=1S/C14H20N2O7/c17-11(3-6-16-12(18)1-2-13(16)19)15-5-8-23-10-9-22-7-4-14(20)21/h1-2H,3-10H2,(H,15,17)(H,20,21)

SMILES

C1=CC(=O)N(C1=O)CCC(=O)NCCOCCOCCC(=O)O

Mal-amido-PEG2-acid, is designed to connect a ligand-bearing warhead to an E3-recruiting moiety through a polyethylene glycol-based spacer that supports favorable solubility and conformational flexibility. Its amide linkage and terminal carboxylic acid enable robust, modular assembly of targeted protein degraders, facilitating systematic optimization of linker length, polarity, and attachment geometry. The following sections describe its structural features and practical reactivity for PROTAC construction in detail below.

Structure: The linker contains a short polyethylene glycol segment providing hydrophilicity and conformational mobility, flanked by an amide connection and a terminal carboxylic acid. It includes an ester/amide-compatible carbonyl environment and ether oxygen atoms that can engage in hydrogen bonding, influencing overall polarity and aqueous behavior.

Reactivity: The terminal carboxylic acid and the amide functionality support standard PROTAC coupling strategies such as carbodiimide-mediated amide bond formation with amine-bearing partners, or activation of the acid for subsequent nucleophilic substitution. Typical assembly is performed under mild, anhydrous-to-semi-anhydrous conditions using coupling reagents and base in compatible polar solvents. The mechanism relies on acid activation to form an intermediate that is attacked by a nucleophile to yield stable amide-linked conjugates, preserving linker integrity.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂