Name: Amino-PEG4-alcohol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in Water (50 mg/ml; 25875 mm; need ultrasonic)

Appearance

Pale Yellow Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature

IUPACName

2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol

Synonyms

2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol; 1-Amino-3,6,9-Trioxaundecanyl-11-ol

Boiling Point

301.6±27.0 °C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

ANOJXMUSDYSKET-UHFFFAOYSA-N

InChI

InChI=1S/C8H19NO4/c9-1-3-11-5-7-13-8-6-12-4-2-10/h10H,1-9H2

SMILES

C(COCCOCCOCCO)N

Biological Activity

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	5.1749 mL	25.8746 mL	51.7491 mL
5 mM	1.0350 mL	5.1749 mL	10.3498 mL
10 mM	0.5175 mL	2.5875 mL	5.1749 mL

Amino-PEG4-alcohol is a polyethylene glycol-based linker featuring a terminal primary amine and a hydroxyl group, enabling versatile conjugation strategies in PROTAC architectures. Its ether-rich, flexible backbone supports effective spatial presentation of ligands while improving solubility and reducing nonspecific interactions. The linker’s bifunctionality makes it well suited for stepwise assembly of targeted protein degraders, where detailed synthetic considerations for coupling and functionalization are provided below.

Structure: The molecule contains a PEG chain composed of repeating ether units, terminating in a primary amine and a primary alcohol. Its flexible polyether segment provides conformational adaptability, while the amine and hydroxyl enable formation of stable linkages via common coupling chemistries and hydrogen-bonding interactions.

Reactivity: The terminal amine can be converted into activated intermediates (for example, amide formation via carboxylic acid activation) or used in reductive amination or carbamate-forming reactions, depending on the partner functional group. The alcohol can be functionalized through esterification or etherification under standard dehydrating or activating conditions. Typical coupling workflows employ amine-compatible bases, polar aprotic solvents, and carbodiimide or similar activation systems, following established PROTAC linker-conjugation principles.

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂