Amino-PEG4-alcohol

≥95%

Soluble in Water (50 mg/ml; 25875 mm; need ultrasonic)

Pale Yellow Oily Matter

Store at 2-8°C

Room temperature

2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol

2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol; 1-Amino-3,6,9-Trioxaundecanyl-11-ol

301.6±27.0 °C at 760 mmHg

1.1±0.1 g/cm3

ANOJXMUSDYSKET-UHFFFAOYSA-N

InChI=1S/C8H19NO4/c9-1-3-11-5-7-13-8-6-12-4-2-10/h10H,1-9H2

C(COCCOCCOCCO)N

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .