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Amino-PEG4-alcohol - CAS 86770-74-3

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Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Molecular Formula
C8H19NO4
Molecular Weight
193.24

Amino-PEG4-alcohol

    • Specification
      • Related CAS
        933789-97-0 (polymer)
        Purity
        ≥95%
        Solubility
        Soluble in Water (50 mg/ml; 25875 mm; need ultrasonic)
        Appearance
        Pale Yellow Oily Matter
        Storage
        Store at 2-8°C
        Shipping
        Room temperature
        IUPAC Name
        2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol
        Synonyms
        2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol; 1-Amino-3,6,9-Trioxaundecanyl-11-ol
    • Properties
      • Boiling Point
        301.6±27.0 °C at 760 mmHg
        Density
        1.1±0.1 g/cm3
        InChI Key
        ANOJXMUSDYSKET-UHFFFAOYSA-N
        InChI
        InChI=1S/C8H19NO4/c9-1-3-11-5-7-13-8-6-12-4-2-10/h10H,1-9H2
        Canonical SMILES
        C(COCCOCCOCCO)N
        Biological Activity
        Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .
    • Preparing Stock Solutions
      • ConcentrationVolumeMass1 mg5 mg10 mg
        1 mM5.1749 mL25.8746 mL51.7491 mL
        5 mM1.0350 mL5.1749 mL10.3498 mL
        10 mM0.5175 mL2.5875 mL5.1749 mL
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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