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t-Boc-N-amido-PEG4-bromide - CAS 1076199-21-7

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t-Boc-N-amido-PEG3-bromide is a PEG linker containing a bromide group and a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

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Molecular Formula
C13H26BrNO5
Molecular Weight
356.25

t-Boc-N-amido-PEG4-bromide

    • Specification
      • Purity
        ≥97.0%
        Solubility
        Soluble in Chloroform (Slightly), Methanol (Slightly)
        Appearance
        Pale Yellow or Colorless Oily Matter
        Shelf Life
        0-4°C for short term (days to weeks), or -20°C for long term (months).
        Storage
        Store at 2-8°C under inert atmosphere
        Shipping
        Room temperature
        IUPAC Name
        tert-butyl N-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethyl]carbamate
        Synonyms
        Br-PEG3-NHBoc; Boc-NH-PEG3-Br; BocNH-PEG3-CH2CH2Br; N-Boc-PEG3-bromide; tert-Butyl (2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)ethyl)carbamate; 1-Boc-amino-3,6,9-trioxaundecanyl-11-bromide; 2-{2-[2-(2-Boc-aminoethoxy)ethoxy]ethoxy}ethyl Bromide; 13-Bromo-5,8,11-trioxa-2-azatridecanoic Acid 1,1-Dimethylethyl Ester; 2-Methyl-2-propanyl (2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethyl)carbamate; Carbamic acid, N-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
    • Properties
      • Boiling Point
        422.08 °C at 760 mmHg (Predicted)
        Density
        1.238±0.1 g/cm3
        InChI Key
        GNDQONYTPMGMTM-UHFFFAOYSA-N
        InChI
        InChI=1S/C13H26BrNO5/c1-13(2,3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11H2,1-3H3,(H,15,16)
        Canonical SMILES
        CC(C)(C)OC(=O)NCCOCCOCCOCCBr
        Biological Activity
        N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
    • Preparing Stock Solutions
      • ConcentrationVolumeMass1 mg5 mg10 mg
        1 mM2.8070 mL14.0351 mL28.0702 mL
        5 mM0.5614 mL2.8070 mL5.6140 mL
        10 mM0.2807 mL1.4035 mL2.8070 mL
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L

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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