Name: Mal-PEG2-COOtBu
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoate

Synonyms

Mal-PEG2-t-butyl ester; Mal-PEG2-Boc; tert-butyl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)-2-ethoxypropanoate

Boiling Point

428.7±30.0 °C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

XWPBPQDTQUEMBX-UHFFFAOYSA-N

InChI

InChI=1S/C15H23NO6/c1-15(2,3)22-14(19)6-8-20-10-11-21-9-7-16-12(17)4-5-13(16)18/h4-5H,6-11H2,1-3H3

SMILES

CC(C)(C)OC(=O)CCOCCOCCN1C(=O)C=CC1=O

Mal-PEG2-COOtBu, is designed to provide a flexible polyethylene glycol spacer terminating in a protected carboxylate functionality. Its ether-rich PEG segment can improve solubility and conformational adaptability between the ligand-binding modules, supporting efficient ternary complex formation in targeted protein degradation workflows. The following points describe the structure and the practical reactivity considerations for incorporating this linker into PROTAC constructs in detail below.

Structure: The linker contains a PEG-based ethylene glycol unit connected through ether linkages, providing a hydrophilic, conformationally flexible backbone. A malemide-derived electrophilic motif is present alongside a tert-butyl-protected carboxylate, featuring an ester that can be unmasked under standard deprotection conditions.

Reactivity: Mal-PEG2-COOtBu is suitable for PROTAC assembly via electrophile–nucleophile coupling, where the malemide functionality reacts with appropriate nucleophiles (commonly thiols or amines) under mild conditions to form stable thioether or amide linkages. PROTAC synthesis typically employs polar aprotic solvents and base/acid systems compatible with PEG linkers, while the tert-butyl ester is used as a protected handle that can be deprotected prior to final conjugation steps.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂