Methyltetrazine-PEG13-Boc
Cat No.: BP-501902
4.5 
Methyltetrazine-PEG13-Boc is a PEG-based PROTAC linker featuring a methyltetrazine functional group for rapid bioorthogonal ligation and a Boc-protected handle that can be used to control reactivity during synthesis and subsequent conjugation steps. Structurally, it consists of a long, flexible polyethylene glycol chain that spatially separates the two reactive ends, improving effective reach and reducing steric hindrance when assembling ternary or multicomponent targeted degradation constructs. In PROTAC design, the methyltetrazine moiety enables inverse-electron-demand Diels–Alder reactions with trans-cyclooctene or related strained-alkene partners, allowing researchers to modularly connect ligand-bearing warheads to E3 ligase recruiters or other functional domains under mild conditions. The PEG13 architecture is particularly valuable for tuning linker length and hydrophilicity to enhance solubility and maintain productive ternary complex formation, supporting systematic optimization of degradation potency and selectivity in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This Methyltetrazine-PEG13-Boc linker is designed for modular PROTAC assembly, providing a chemically addressable tetrazine handle for bioorthogonal conjugation alongside a PEG-based spacer that can improve solubility and presentation of binding motifs. The Boc-protected functionality supports controlled downstream coupling strategies, enabling researchers to tailor linker length, reactivity, and conjugation order. Detailed structural and reactivity considerations are provided below.
Structure: The linker combines a methyltetrazine moiety with a polyethylene glycol spacer and a Boc-protected group. It contains heteroaromatic nitrogen-rich functionality, ether linkages from the PEG chain, and carbamate chemistry associated with Boc protection. These features support aqueous compatibility and selective reactivity of the tetrazine component.
Reactivity: The methyltetrazine group is suited to strain-promoted inverse electron-demand Diels–Alder ligation with appropriate strained dienophiles under mild, aqueous-compatible conditions. The PEG spacer generally tolerates common coupling solvents used for PROTAC synthesis. Boc functionality enables orthogonal protection/deprotection workflows, typically using acid-mediated deprotection prior to amide or carbamate-forming coupling steps. Choice of solvent and pH should preserve tetrazine integrity and the stability of reactive intermediates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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