Bromo-PEG5-bromide
CAS No.: 67705-77-5
Cat No.: BP-500702
Purity: ≥95%
4.5 
Bromo-PEG5-bromide is a bifunctional polyethylene glycol linker bearing terminal bromides, providing a flexible, hydrophilic chain that can be used to connect PROTAC components through ether-forming or substitution-based conjugation strategies. Structurally, it comprises a short PEG spacer with brominated leaving groups at both ends, enabling controlled linkage to nucleophilic sites on ligands such as cereblon-recruiting motifs or target-binding warheads. In PROTAC design, PEG linkers are widely used to tune effective molarity, reduce steric clashes, and improve solubility, thereby facilitating productive ternary complex formation between the recruited E3 ligase and the target protein. This reagent is valuable for researchers seeking modular synthesis of degraders, allowing systematic variation of linker length and attachment chemistry to optimize degradation potency and selectivity while maintaining aqueous compatibility for biochemical and cell-based assays.
Structure of 67705-77-5
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Bromo-PEG5-bromide is a PEG-based bifunctional linker designed for modular assembly of PROTACs, enabling efficient spatial separation and flexible conformational tuning between a ligand for the target protein and an E3 ligase recruiter. Its two terminal bromides support robust synthetic coupling strategies commonly used in targeted protein degradation workflows. The linker’s ether-rich scaffold enhances solubility and can reduce steric constraints, improving the practicality of iterative PROTAC synthesis. Detailed structural and reactivity considerations are provided below.
Structure: The molecule is a poly(ethylene glycol) chain bearing bromide leaving groups at both termini. It contains repeating ether linkages that confer flexibility, polarity, and hydrogen-bond-accepting character, while the C–Br bonds provide electrophilic handles for substitution. The overall architecture supports formation of stable carbon–heteroatom connectivity in PROTAC constructs.
Reactivity: Bromo-PEG5-bromide is typically used in nucleophilic substitution reactions where the terminal bromides are displaced by nucleophiles such as amines or other carbon- and heteroatom-based nucleophiles. Practical conditions often involve polar aprotic solvents, controlled base strength, and temperature optimization to balance substitution efficiency and minimize side reactions. The reaction proceeds via an SN-type substitution mechanism for alkyl bromides, with product formation driven by nucleophile strength and solvation effects.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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