mPEG4-amine
CAS No.: 85030-56-4
Cat No.: BP-500641
Purity: ≥95%
4.5 
mPEG4-amine is a methoxy-terminated polyethylene glycol (PEG) linker bearing a primary amine at the terminus, providing a short, hydrophilic chain that can be readily functionalized for bioconjugation. Structurally, it consists of a methoxy-capped PEG segment of limited length connected to an amine, enabling formation of stable amide or urea linkages with carboxylic-acid–containing partners, or coupling through standard amine-reactive chemistries. In PROTAC and targeted protein degradation workflows, such PEG-amine linkers are commonly used to tune solubility, reduce nonspecific adsorption, and introduce a defined attachment handle for conjugating ligands or other modular components while maintaining sufficient flexibility for productive ternary-complex formation. Its value lies in supporting reproducible linker installation and improving handling and formulation of degraders during synthesis, purification, and in vitro testing, thereby facilitating systematic structure–activity relationship studies.
Structure of 85030-56-4
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This mPEG4-amine linker is an amine-functionalized methoxy-polyethylene glycol intermediate designed for efficient conjugation in PROTAC architectures. Its PEG-based, hydrophilic spacer can improve aqueous compatibility and provide a handle for reliable coupling to targeting ligands or E3-recruiting modules. The flexible ether-rich backbone supports productive linker conformations while minimizing nonspecific interactions, and the subsequent points describe its structural characteristics and practical use in PROTAC construction.
Structure: mPEG4-amine is a methoxy-terminated polyethylene glycol chain bearing a terminal primary amine. The structure features repeating ether linkages along the PEG backbone and a stable C–N bond at the amine terminus, providing a flexible, water-compatible scaffold with a polar, hydrogen-bonding surface.
Reactivity: The terminal primary amine enables standard PROTAC linker assembly via amide formation (using activated carboxylic acids such as NHS esters or acid chlorides), carbamate formation (with activated carbonyl reagents), or reductive amination where appropriate carbonyl partners are available. Coupling is typically performed under mild base conditions in polar aprotic or aqueous-compatible solvents, with common coupling reagents (for activated esters) facilitating nucleophilic acyl substitution.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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