N-(Azido-PEG3)-N-bis(PEG4-acid)
CAS No.: 2112731-54-9
Cat No.: BP-500200
Purity: 98%
4.5 
N-(Azido-PEG3)-N-bis(PEG4-acid) is a branched, multifunctional PEG scaffold. Structurally, it contains a central tertiary amine bearing one azido-PEG3 arm and two PEG4 arms terminated with propionic acid groups. The two carboxylic acids can be activated for amide coupling with amine-bearing components, while the azide provides a separate handle for CuAAC with a terminal alkyne or SPAAC with a strained cyclooctyne. In PROTAC and related targeted protein degradation research, this three-arm architecture can support branched degrader, probe, or multivalent conjugate assembly while maintaining distinct acid and azide chemistries. Its defined architecture allows researchers to evaluate how linker polarity, flexibility, attachment sequence, and terminal-group selection influence conjugate preparation and the spatial requirements of productive target–E3 ligase engagement. Clear assignment of the protected and reactive groups also supports reproducible reaction planning and systematic comparison of alternative linker designs in research-focused targeted protein degradation workflows.
Structure of 2112731-54-9
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N-(Azido-PEG3)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based bifunctional PROTAC linker designed to support modular assembly of targeted protein degraders. Its azide handle enables chemoselective conjugation to compatible partners, while the PEG acid termini provide functional groups commonly used for stable, solubilizing linker architectures. The flexible, hydrophilic PEG framework can improve aqueous compatibility and help tune spatial presentation of binding motifs during PROTAC construction. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains an azide-functionalized PEG segment connected through amide-type connectivity to a bis(PEG acid) portion. Its backbone is dominated by ether linkages typical of PEG, imparting conformational flexibility. The terminal carboxylic acid groups provide hydrophilicity and opportunities for coupling, while the azide offers a bioorthogonal reactive site.
Reactivity: The azide group is suitable for copper-free or copper-catalyzed azide–alkyne cycloaddition, enabling efficient conjugation to alkyne-bearing PROTAC fragments under standard click-chemistry conditions. The carboxylic acid termini are compatible with amide-bond formation using activated carboxyl derivatives and appropriate nucleophiles. Solvents such as polar aprotic media and aqueous buffer systems are commonly used to balance solubility and reaction kinetics, with careful control of pH and reagent stoichiometry to preserve sensitive functional groups.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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