N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5
CAS No.: 2107273-58-3
Cat No.: BP-501106
Purity: 98%
4.5 
N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a multifunctional, Cy5-labeled, PEG-based linker reagent featuring multiple methoxy-terminated oligo(ethylene glycol) segments and a terminal azide handle. Its extended, hydrophilic PEG chain architecture provides solubility and spacing that can reduce steric interference when conjugated to PROTAC components, while the azide group enables bioorthogonal click chemistry for site-specific attachment to complementary alkyne-bearing partners. In PROTAC design, such linkers are used to connect targeting ligands, E3 ligase recruiters, or auxiliary modules (e.g., imaging or enrichment tags) through a stable conjugation step, allowing controlled geometry and improved effective molarity at the ternary-complex interface. The Cy5 fluorophore further supports mechanistic studies by enabling visualization of conjugate formation, cellular uptake, and degradation-associated trafficking. This reagent is therefore valuable for researchers optimizing linker length, flexibility, and conjugation chemistry in targeted protein degradation workflows.
Structure of 2107273-58-3
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker product is designed to integrate multiple polyethylene glycol (PEG) segments with a terminal azide handle and a Cy5 fluorophore-compatible scaffold, enabling modular assembly and tracking of targeted protein degradation constructs. Its PEG-rich architecture supports solubility and flexible linker behavior, while the azide functionality provides a reliable chemical “click” site for conjugation to complementary partners. Detailed structural and synthetic considerations are provided below.
Structure: The linker is a Cy5-bearing, multi-PEG construct featuring ether linkages within PEG chains and terminal azide functionality. It contains amide and ether connectivity that promote conformational flexibility, with a large hydrophilic PEG domain that enhances aqueous compatibility. The Cy5 chromophore enables fluorescence-based monitoring of conjugation and assembly.
Reactivity: The azide group is suitable for copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted azide–alkyne cycloaddition, enabling efficient conjugation to alkyne-functional PROTAC components under mild conditions. Typical workflows use biocompatible solvents such as aqueous alcohol mixtures or buffered aqueous media, with copper catalysts and stabilizing ligands when using CuAAC. Reaction progress can be followed by fluorescence from the Cy5 label.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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