N-(PEG2-C2-acid)-N-bis(PEG2-propargyl)
CAS No.: 2100306-49-6
Cat No.: BP-500255
Purity: 98%
4.5 
N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a heterobifunctional polyethylene glycol (PEG) linker reagent featuring a short PEG2 segment on both sides and terminal propargyl groups for copper-free or copper-catalyzed azide–alkyne cycloaddition. The “C2-acid” motif provides a carboxylic acid handle that enables controlled conjugation to amine- or hydrazide-bearing ligands (e.g., via amide coupling), while the PEG chains impart aqueous solubility and reduce nonspecific hydrophobic interactions, improving PROTAC handling and cellular compatibility. In PROTAC design, this linker serves as a modular spacer that spatially separates the ligand-binding elements and positions them for efficient ternary complex formation by the recruited E3 ligase and target protein. Its orthogonal reactive groups allow sequential assembly of PROTACs with defined architectures, facilitating systematic structure–activity relationship studies and optimization of linker length, flexibility, and conjugation site placement in targeted protein degradation research.
Structure of 2100306-49-6
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N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based PROTAC linker designed to connect targeting ligands through orthogonal, bioorthogonal-compatible reactive handles. Its PEG-rich architecture supports aqueous solubility and conformational flexibility, while the propargyl termini enable efficient conjugation strategies commonly used in targeted protein degradation workflows. The acid functionality further supports robust linker design and downstream coupling, and the detailed Structure and Reactivity parameters are described below.
Structure: The linker comprises a PEG2 framework bearing an internal carboxylic acid motif and two propargyl ether substituents on nitrogen. It contains ether linkages, an amide nitrogen center, and terminal alkyne groups suitable for click-type conjugation. Overall, the PEG segments impart strong hydrophilicity and flexible chain dynamics.
Reactivity: The terminal propargyl groups are suited for copper-catalyzed azide–alkyne cycloaddition or related alkyne-based coupling routes used to assemble PROTACs from azide-functionalized ligands. Typical conditions rely on an appropriate copper catalyst system, an aqueous or mixed solvent environment, and ligand-compatible temperatures to preserve functional groups. The mechanism proceeds via formation of a copper acetylide followed by cycloaddition to the azide, yielding a stable triazole linkage.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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