NH-bis(PEG4-Boc)
CAS No.: 2055041-41-1
Cat No.: BP-500779
4.5 
NH-bis(PEG4-Boc) is a bifunctional, amine-bearing linker reagent incorporating two polyethylene glycol–based arms of defined length, each terminated with a Boc-protected group. Structurally, it provides a flexible PEG spacer that can improve solubility and reduce nonspecific interactions while offering orthogonally protected reactive handles for subsequent synthetic steps. In PROTAC construction, such PEG–Boc linkers are commonly used to connect or tune the spatial relationship between a target-binding ligand and an E3 ligase recruiting element, thereby optimizing the geometry required for productive ternary complex formation. The PEG segments can also mitigate aggregation and enhance handling of bulky conjugates, which is particularly valuable when assembling multi-component degraders. This reagent is therefore useful for researchers seeking modular, solubility-enhancing linker scaffolds and controlled deprotection strategies to generate PROTAC intermediates for targeted protein degradation studies.
Structure of 2055041-41-1
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This branched oligoether linker combines a central secondary amine with protected carboxyl termini. It offers a polar, flexible branch point for sequential attachment of PROTAC components and can support topology screening beyond conventional linear linkers. Its structural and reactive characteristics are presented below.
Structure: A secondary amine connects elongated oligoether arms that terminate as tert-butyl propanoates. Repeating ether bonds provide flexibility and polarity, the amine supplies a nucleophilic branch point, and the ester carbonyls mask carboxyl groups until acid-mediated deprotection is desired.
Reactivity: The secondary amine can be acylated with an activated carboxylic acid or alkylated with a suitable electrophile under basic conditions in an aprotic solvent. Acidic cleavage of the terminal tert-butyl esters then exposes carboxyl groups for carbodiimide- or uronium-mediated amidation. Reaction order, reagent equivalents, and temporary protection should be chosen to avoid overfunctionalization at the branched scaffold.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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