m-PEG4-Boc
CAS No.: 883554-11-8
Cat No.: BP-500856
Purity: >98.0%
4.5 
m-PEG4-Boc is an m-PEG (methoxy-capped polyethylene glycol) linker bearing a Boc-protected functional group, providing a flexible, hydrophilic chain length suitable for PROTAC synthesis and other targeted conjugation strategies. Structurally, it combines a PEG spacer with a tert-butoxycarbonyl (Boc) protected handle, enabling controlled functionalization under standard organic conditions while maintaining solubility and reducing nonspecific hydrophobic interactions. In PROTAC design, PEG linkers are widely used to tune the spatial relationship between the ligand-binding modules and to improve the effective reach and conformational freedom required for ternary complex formation. The Boc group allows staged coupling workflows, where deprotection can be performed to reveal a reactive amine for subsequent amide/urea formation with activated carboxylic acids or isocyanates. This linker is valuable for researchers seeking reproducible conjugation chemistry and improved aqueous handling during targeted protein degradation construct optimization.
Structure of 883554-11-8
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m-PEG4-Boc is a polyethylene glycol-based PROTAC linker bearing a Boc-protected functional handle, designed to provide solubility, conformational flexibility, and a chemically addressable attachment point for assembling targeted protein degraders. Its PEG architecture helps modulate linker hydrophilicity and can support productive ternary complex formation, while Boc protection enables controlled downstream functionalization. The following sections describe the linker’s structure and practical reactivity considerations for PROTAC synthesis.
Structure: The linker consists of an m-substituted aromatic core connected to a short PEG chain and a Boc-protected group. It contains ether linkages within the PEG segment, an aromatic ring, and carbamate functionality from the Boc moiety, yielding a polar, hydrophilic scaffold with stable covalent connectivity.
Reactivity: Boc-protected intermediates are typically deprotected under mild acid conditions to generate a reactive amine for subsequent coupling. PROTAC assembly commonly employs amide or carbamate-forming reactions between the liberated amine and activated carboxylic acid derivatives (e.g., activated esters) using standard coupling reagents in polar aprotic solvents. The overall strategy follows protection–deprotection control to preserve sensitive ligands and maintain linker integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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