t-Boc-N-amido-PEG12-amine
CAS No.: 1642551-09-4
Cat No.: BP-501514
Purity: ≥95%
4.5 
t-Boc-N-amido-PEG12-amine is a protected, terminally functionalized polyethylene glycol (PEG) linker featuring a Boc-protected amine at one end and an amide-linked PEG chain terminating in a primary amine at the other. The PEG segment provides a flexible, hydrophilic spacer that can reduce steric interference between a ligand-binding moiety and the recruited E3 ligase module, while the amide/amine functionality enables reliable conjugation chemistry. In PROTAC construction, this linker is used to connect two protein-interacting components through stable amide or urea-forming reactions after appropriate activation of the terminal amine, thereby positioning the two ligands at an effective distance and relative orientation for productive ternary complex formation. Its long, ether-rich chain is commonly leveraged to improve solubility and to tune linker length-dependent degradation potency and selectivity. This makes it a valuable building block for systematic linker optimization in targeted protein degradation workflows.
Structure of 1642551-09-4
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t-Boc-N-amido-PEG12-amine is a polyethylene glycol-based PROTAC linker building block designed to provide conformational flexibility, improved solubility, and a handle for controlled amide coupling. Its protected amine enables sequential synthetic strategies commonly used in targeted protein degradation workflows, facilitating the assembly of bifunctional degraders with reliable attachment points to ligands. The following sections describe its structure and practical reactivity considerations in detail.
Structure: The molecule contains a PEG oligomer segment with a terminal primary amine and an amine protected as a tert-butoxycarbonyl (t-Boc) carbamate at the opposite end. It features ether linkages along the PEG chain and a Boc carbamate carbonyl, with a protecting group that can be removed under acidic conditions.
Reactivity: For PROTAC assembly, the t-Boc group is typically removed using mild acid to reveal the free amine, enabling formation of new amide bonds with activated carboxylic acids or carboxylate derivatives. Amide coupling is commonly performed using standard peptide-coupling reagent systems in polar aprotic solvents, proceeding via activation of the acid followed by nucleophilic acyl substitution by the liberated amine.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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