PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-201033	L14AR	2677798-51-3	CRBN	HMGCR	Inquiry
Molecular Weight: 1026.18 Molecular Formula: C57H64FN7O10 Density: 1.34±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201034	L15AR	2677798-52-4	CRBN	HMGCR	Inquiry
Molecular Weight: 1040.20 Molecular Formula: C58H66FN7O10 Density: 1.33±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201035	L16AR	2677798-53-5	CRBN	HMGCR	Inquiry
Molecular Weight: 1054.23 Molecular Formula: C59H68FN7O10 Density: 1.32±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201036	L17AR	2677798-54-6	CRBN	HMGCR	Inquiry
Molecular Weight: 1068.26 Molecular Formula: C60H70FN7O10 Density: 1.31±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201037	L18AR	2677798-55-7	CRBN	HMGCR	Inquiry
Molecular Weight: 1082.28 Molecular Formula: C61H72FN7O10 Density: 1.31±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201038	(2S,4R)-1-((S)-16-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,14-dioxo-3-oxa-2,7,15-triazaheptadecan-17-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2672512-41-1	VHL	MEK1 MEK2	Inquiry
Molecular Weight: 1005.94 Molecular Formula: C45H55F3IN7O6S Density: 1.414±0.06 g/cm3 Description: It is a first-in-class MEK1/2 degrader, which degrades MEK1 and MEK2 in a VHL E3 ligase- and proteasome-dependent manner.
	BPL-201039	(2S,4R)-1-((S)-20-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,18-dioxo-3-oxa-2,7,19-triazahenicosan-21-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2672512-42-2	VHL	MEK1 MEK2	Inquiry
Molecular Weight: 1062.05 Molecular Formula: C49H63F3IN7O6S Density: 1.366±0.06 g/cm3 Description: It is a first-in-class MEK1/2 degrader, which degrades MEK1 and MEK2 in a VHL E3 ligase- and proteasome-dependent manner.
	BPL-201040	(2S,4R)-1-((S)-20-(tert-Butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,18-dioxo-3,10,13,16-tetraoxa-2,7,19-triazahenicosan-21-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2672512-43-3	VHL	MEK1 MEK2	Inquiry
Molecular Weight: 1067.97 Molecular Formula: C46H57F3IN7O9S Density: 1.430±0.06 g/cm3 Description: It is a first-in-class MEK1/2 degrader, which degrades MEK1 and MEK2 in a VHL E3 ligase- and proteasome-dependent manner.
	BPL-201041	N-(3-((2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)amino)propoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide	2581109-59-1	CRBN	MEK1 MEK2	Inquiry
Molecular Weight: 808.55 Molecular Formula: C33H32F3IN6O7 Density: 1.626±0.06 g/cm3 Description: It is a first-in-class MEK1/2 degrader, which degrades MEK1 and MEK2 in a VHL E3 ligase- and proteasome-dependent manner.
	BPL-201042	N-(3-((2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)propoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide	2581109-41-1	CRBN	MEK1 MEK2	Inquiry
Molecular Weight: 764.50 Molecular Formula: C31H28F3IN6O6 Density: 1.669±0.06 g/cm3 Description: It is a first-in-class MEK1/2 degrader, which degrades MEK1 and MEK2 in a VHL E3 ligase- and proteasome-dependent manner.
	BPL-201043	MS432	2672512-44-4	VHL	MEK1 MEK2	Inquiry
Molecular Weight: 1076.08 Molecular Formula: C50H65F3IN7O6S Density: 1.354±0.06 g/cm3 Description: It is a first-in-class degrader of MEK1/2, which potently and selectively degrades MEK1 and MEK2 in a VHL E3 ligase- and proteasome-dependent manner and inhibits ERK phosphorylation in cells.
	BPL-201044	4-((1-Butyl-3-(4-(2-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2366243-69-6	CRBN	HDAC6	Inquiry
Molecular Weight: 737.77 Molecular Formula: C37H39N9O8 Density: 1.46±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.
	BPL-201045	4-((1-Butyl-3-(4-(3-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)propoxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2366248-57-7	CRBN	HDAC6	Inquiry
Molecular Weight: 751.80 Molecular Formula: C38H41N9O8 Density: 1.45±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.
	BPL-201046	4-((1-Butyl-3-(4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)butoxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2366247-08-5	CRBN	HDAC6	Inquiry
Molecular Weight: 765.83 Molecular Formula: C39H43N9O8 Density: 1.43±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.
	BPL-201047	4-((1-Butyl-3-(4-((5-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)pentyl)oxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2366246-02-6	CRBN	HDAC6	Inquiry
Molecular Weight: 779.86 Molecular Formula: C40H45N9O8 Density: 1.41±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.
	BPL-201048	4-((1-Butyl-3-(4-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)hexyl)oxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2366248-21-5	CRBN	HDAC6	Inquiry
Molecular Weight: 793.88 Molecular Formula: C41H47N9O8 Density: 1.40±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.
	BPL-201049	4-((1-Butyl-3-(4-(2-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-1H-1,2,3-triazol-1-yl)ethoxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2408840-11-7	CRBN	HDAC6	Inquiry
Molecular Weight: 751.80 Molecular Formula: C38H41N9O8 Density: 1.45±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.
	BPL-201050	4-((1-Butyl-3-(4-(3-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-1H-1,2,3-triazol-1-yl)propoxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2366248-10-2	CRBN	HDAC6	Inquiry
Molecular Weight: 765.83 Molecular Formula: C39H43N9O8 Density: 1.43±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.
	BPL-201051	4-((1-Butyl-3-(4-(4-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-1H-1,2,3-triazol-1-yl)butoxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2366245-53-4	CRBN	HDAC6	Inquiry
Molecular Weight: 779.86 Molecular Formula: C40H45N9O8 Density: 1.41±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.
	BPL-201052	4-((1-Butyl-3-(4-(2-(4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propyl)-1H-1,2,3-triazol-1-yl)ethoxy)phenyl)ureido)methyl)-N-hydroxybenzamide	2366248-54-4	CRBN	HDAC6	Inquiry
Molecular Weight: 765.83 Molecular Formula: C39H43N9O8 Density: 1.43±0.1 g/cm3 Description: It is a multifunctional histone deacetylase 6 (HDAC6) degrader with potent antimyeloma activity.