PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-200993	(2S,4R)-1-((S)-2-(3-(3-(4-((1-(2,6-Difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidin-1-yl)-3-oxopropoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide		VHL	BRAF V600E	Inquiry
Molecular Weight: 1098.31 Molecular Formula: C54H65F2N11O8S2 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200994	(2S,4R)-1-((S)-2-(3-(2-(3-(4-((1-(2,6-Difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidin-1-yl)-3-oxopropoxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide		VHL	BRAF V600E	Inquiry
Molecular Weight: 1142.37 Molecular Formula: C56H69F2N11O9S2 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200995	(2S,4R)-1-((S)-2-(tert-Butyl)-16-(4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidin-1-yl)-4,16-dioxo-7,10,13-trioxa-3-azahexadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide		VHL	BRAF V600E	Inquiry
Molecular Weight: 1186.42 Molecular Formula: C58H73F2N11O10S2 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200996	VH-PEG4-BI	2504050-84-2	VHL	BRAF V600E	Inquiry
Molecular Weight: 1230.47 Molecular Formula: C60H77F2N11O11S2 Density: 1.37±0.1 g/cm3 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200997	(2S,4R)-1-((S)-2-(tert-Butyl)-22-(4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidin-1-yl)-4,22-dioxo-7,10,13,16,19-pentaoxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide		VHL	BRAF V600E	Inquiry
Molecular Weight: 1274.53 Molecular Formula: C62H81F2N11O12S2 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200998	P13A	2338847-23-5	CRBN	HMGCR	Inquiry
Molecular Weight: 1027.12 Molecular Formula: C55H59FN8O11 Density: 1.40±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-200999	P14A	2338847-31-5	CRBN	HMGCR	Inquiry
Molecular Weight: 1041.15 Molecular Formula: C56H61FN8O11 Density: 1.39±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201000	P15A	2338847-32-6	CRBN	HMGCR	Inquiry
Molecular Weight: 1055.17 Molecular Formula: C57H63FN8O11 Density: 1.38±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201001	P16A	2338847-25-7	CRBN	HMGCR	Inquiry
Molecular Weight: 1071.17 Molecular Formula: C57H63FN8O12 Density: 1.39±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201002	P17A	2338847-34-8	CRBN	HMGCR	Inquiry
Molecular Weight: 1085.18 Molecular Formula: C58H65FN8O12 Density: 1.38±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201003	P18A	2338847-36-0	CRBN	HMGCR	Inquiry
Molecular Weight: 1099.23 Molecular Formula: C59H67FN8O12 Density: 1.37±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201004	P19A	2338847-27-9	CRBN	HMGCR	Inquiry
Molecular Weight: 1115.23 Molecular Formula: C59H67FN8O13 Density: 1.37±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201005	P20A	2338847-39-3	CRBN	HMGCR	Inquiry
Molecular Weight: 1129.25 Molecular Formula: C60H69FN8O13 Density: 1.37±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201006	P21A	2338847-41-7	CRBN	HMGCR	Inquiry
Molecular Weight: 1143.28 Molecular Formula: C61H71FN8O13 Density: 1.36±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201007	P22A	2338847-29-1	CRBN	HMGCR	Inquiry
Molecular Weight: 1159.28 Molecular Formula: C61H71FN8O14 Density: 1.36±0.1 g/cm3 Description: P22A can reduce the level of HMGCR protein and effectively block cholesterol biosynthesis with less compensatory upregulation of HMGCR.
	BPL-201008	P23A	2338847-43-9	CRBN	HMGCR	Inquiry
Molecular Weight: 1173.31 Molecular Formula: C62H73FN8O14 Density: 1.36±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201009	P24A	2677798-34-2	CRBN	HMGCR	Inquiry
Molecular Weight: 1187.33 Molecular Formula: C63H75FN8O14 Density: 1.35±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201010	P25A	2677798-35-3	CRBN	HMGCR	Inquiry
Molecular Weight: 1203.33 Molecular Formula: C63H75FN8O15 Density: 1.35±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201011	P26A	2677798-36-4	CRBN	HMGCR	Inquiry
Molecular Weight: 1217.36 Molecular Formula: C64H77FN8O15 Density: 1.35±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).
	BPL-201012	P27A	2677798-37-5	CRBN	HMGCR	Inquiry
Molecular Weight: 1231.39 Molecular Formula: C65H79FN8O15 Density: 1.34±0.1 g/cm3 Description: It is a PROTAC that overcomes statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).