PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-200973	N-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)hexanamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 853.91 Molecular Formula: C43H41F2N7O8S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200974	N-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)propanamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 855.88 Molecular Formula: C42H39F2N7O9S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200975	N-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)heptanamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 867.93 Molecular Formula: C44H43F2N7O8S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200976	N-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octanamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 881.96 Molecular Formula: C45H45F2N7O8S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200977	N-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-3-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)propanamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 899.93 Molecular Formula: C44H43F2N7O10S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200978	N-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethoxy)propanamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 943.98 Molecular Formula: C46H47F2N7O11S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200979	N-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 988.04 Molecular Formula: C48H51F2N7O12S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200980	N-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-amide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 1032.09 Molecular Formula: C50H55F2N7O13S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200981	N-(3-(5-((1-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoyl)piperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 882.95 Molecular Formula: C43H44F2N10O7S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200982	N-(3-(5-((1-(5-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentanoyl)piperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 896.98 Molecular Formula: C44H46F2N10O7S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200983	N-(3-(5-((1-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoyl)piperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 911.01 Molecular Formula: C45H48F2N10O7S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200984	N-(3-(5-((1-(3-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoyl)piperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 912.98 Molecular Formula: C44H46F2N10O8S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200985	N-(3-(5-((1-(7-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanoyl)piperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 925.03 Molecular Formula: C46H50F2N10O7S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200986	N-(3-(5-((1-(8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octanoyl)piperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 939.06 Molecular Formula: C47H52F2N10O7S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200987	N-(3-(5-((1-(3-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanoyl)piperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide		CRBN	BRAF V600E	Inquiry
Molecular Weight: 957.03 Molecular Formula: C46H50F2N10O9S Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200988	P4B	2485722-76-5	CRBN	BRAF V600E	Inquiry
Molecular Weight: 1045.14 Molecular Formula: C50H58F2N10O11S Density: 1.46±0.1 g/cm3 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200989	P5B	2485722-77-6	CRBN	BRAF V600E	Inquiry
Molecular Weight: 1089.19 Molecular Formula: C52H62F2N10O12S Density: 1.44±0.1 g/cm3 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200990	N1-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-N5-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)glutaramide		VHL	BRAF V600E	Inquiry
Molecular Weight: 1011.19 Molecular Formula: C51H56F2N8O8S2 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200991	N1-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)-N6-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)adipamide		VHL	BRAF V600E	Inquiry
Molecular Weight: 1025.21 Molecular Formula: C52H58F2N8O8S2 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.
	BPL-200992	(2S,4R)-1-((S)-2-(3-(3-((4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)amino)-3-oxopropoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide		VHL	BRAF V600E	Inquiry
Molecular Weight: 1041.21 Molecular Formula: C52H58F2N8O9S2 Description: It is a thalidomide-based heterobifunctional PROTAC that induces selective degradation of BRAF-V600E, but not the wild-type BRAF.