PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-200913	IY-IY-PEG3-nutlin	2569202-21-5	MDM2	TRKC	Inquiry
Molecular Weight: 1875.01 Molecular Formula: C92H122Cl2N24O15 Density: 1.40±0.1 g/cm3 Description: It is a potent proteolysis targeting chimeric (PROTAC) for TrkC degradation in metastatic breast cancer cells.
	BPL-200914	IY-IY-PEG5-nutlin	2569202-22-6	MDM2	TRKC	Inquiry
Molecular Weight: 1963.12 Molecular Formula: C96H130Cl2N24O17 Density: 1.39±0.1 g/cm3 Description: It is a potent proteolysis targeting chimeric (PROTAC) for TrkC degradation in metastatic breast cancer cells.
	BPL-200915	N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-N-[2-[2-[2-[[2-[[(E)-[3-[(1E,3E,5E,7E)-8-carboxy-3,7-dimethyl-1,3,5,7-octatetraen-1-yl]-2,4,4-trimethyl-2-cyclohexen-1-ylidene]amino]oxy]acetyl]amino]ethoxy]ethoxy]ethyl]-β-phenyl-L-phenylalaninamide	1384275-50-6	IAP	CRABP-II	Inquiry
Molecular Weight: 1062.36 Molecular Formula: C60H83N7O10 Density: 1.19±0.1 g/cm3 Description: It is a proteolysis targeting chimeric (PROTAC) that can induce efficient degradation of CRABP-II.
	BPL-200916	NP6	2439058-22-5	CRBN	HDAC6	Inquiry
Molecular Weight: 751.80 Molecular Formula: C38H41N9O8 Density: 1.44±0.1 g/cm3 Description: It is a potent PROTAC that selectively degrades HDAC6 protein.
	BPL-200917	NP8	2439058-23-6	CRBN	HDAC6	Inquiry
Molecular Weight: 795.85 Molecular Formula: C40H45N9O9 Density: 1.42±0.1 g/cm3 Description: It is a potent PROTAC that selectively degrades HDAC6 protein.
	BPL-200918	NP9	2439058-24-7	CRBN	HDAC6	Inquiry
Molecular Weight: 839.91 Molecular Formula: C42H49N9O10 Density: 1.40±0.1 g/cm3 Description: It is a potent PROTAC that selectively degrades HDAC6 protein.
	BPL-200919	NP10	2439058-25-8	CRBN	HDAC6	Inquiry
Molecular Weight: 883.96 Molecular Formula: C44H53N9O11 Density: 1.39±0.1 g/cm3 Description: It is a potent PROTAC that selectively degrades HDAC6 protein.
	BPL-200920	TD-158	2305936-47-2	VHL	CRBN	Inquiry
Molecular Weight: 842.03 Molecular Formula: C44H55N7O8S Boiling Point: 1101.1±65.0°C at 760 Torr Density: 1.315±0.06 g/cm3 Description: It is a von Hippel-Lindau-Cereblon (VHL-CRBN) heterodimerized PROTAC that induces the degradation of CRBN, but not VHL.
	BPL-200921	TD-156	2305936-45-0	VHL	CRBN	Inquiry
Molecular Weight: 813.98 Molecular Formula: C42H51N7O8S Boiling Point: 1096.4±65.0°C at 760 Torr Density: 1.340±0.06 g/cm3 Description: It is a von Hippel-Lindau-Cereblon (VHL-CRBN) heterodimerized PROTAC that induces the degradation of CRBN, but not VHL.
	BPL-200922	TD-759	2305936-64-3	VHL	CRBN	Inquiry
Molecular Weight: 927.14 Molecular Formula: C48H62N8O9S Boiling Point: 1183.5±65.0°C at 760 Torr Density: 1.301±0.06 g/cm3 Description: It is a von Hippel-Lindau-Cereblon (VHL-CRBN) heterodimerized PROTAC that induces the degradation of CRBN, but not VHL.
	BPL-200923	TD-760	2305936-65-4	VHL	CRBN	Inquiry
Molecular Weight: 928.12 Molecular Formula: C48H61N7O10S Boiling Point: 1172.4±65.0°C at 760 Torr Density: 1.295±0.06 g/cm3 Description: It is a von Hippel-Lindau-Cereblon (VHL-CRBN) heterodimerized PROTAC that induces the degradation of CRBN, but not VHL.
	BPL-200924	TD-033	2305936-52-9	VHL	CRBN	Inquiry
Molecular Weight: 827.96 Molecular Formula: C42H49N7O9S Boiling Point: 1136.3±65.0°C at 760 Torr Density: 1.370±0.06 g/cm3 Description: It is a von Hippel-Lindau-Cereblon (VHL-CRBN) heterodimerized PROTAC that induces the degradation of CRBN, but not VHL.
	BPL-200925	SNIPER(ABL)-056	2222355-82-8	cIAP1	BCR-ABL	Inquiry
Molecular Weight: 1026.69 Molecular Formula: C50H60ClN11O7S2 Density: 1.353±0.06 g/cm3 Description: It is a protein degradation inducer of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitor and IAP ligand.
	BPL-200926	SNIPER(ABL)-038	2095244-51-0	cIAP1	BCR-ABL	Inquiry
Molecular Weight: 1070.74 Molecular Formula: C52H64ClN11O8S2 Density: 1.341±0.06 g/cm3 Description: It is a protein degradation inducer of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitor and IAP ligand.
	BPL-200927	SNIPER(ABL)-057	2222354-59-6	cIAP1	BCR-ABL	Inquiry
Molecular Weight: 1158.85 Molecular Formula: C56H72ClN11O10S2 Density: 1.321±0.06 g/cm3 Description: It is a protein degradation inducer of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitor and IAP ligand.
	BPL-200928	SNIPER(ABL)-021	2222354-04-1	cIAP1	BCR-ABL	Inquiry
Molecular Weight: 987.12 Molecular Formula: C50H57F3N8O8S Boiling Point: 1080.2±65.0°C at 760 Torr Density: 1.299±0.06 g/cm3 Description: It is a protein degradation inducer of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitor and IAP ligand.
	BPL-200929	N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucyl-N-[2-[4-[(1Z)-1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]-N-methyl-β-alaninamide	1428546-74-0	cIAP1	ER	Inquiry
Molecular Weight: 734.94 Molecular Formula: C44H54N4O6 Boiling Point: 958.0±65.0°C at 760 Torr Density: 1.175±0.06 g/cm3 Description: It is an estrogen receptor (ER) degradation inducer that induces CIAP1-mediated ERα ubiquitination, leading to its proteasome degradation.
	BPL-200930	(αS,βR)-β-Amino-α-hydroxy-N-[(1S)-1-[[[5-[[2-[4-[(1Z)-1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]methylamino]-5-oxopentyl]amino]carbonyl]-3-methylbutyl]benzenebutanamide	1428546-75-1	cIAP1	ER	Inquiry
Molecular Weight: 762.99 Molecular Formula: C46H58N4O6 Boiling Point: 972.7±65.0°C at 760 Torr Density: 1.159±0.06 g/cm3 Description: It is an estrogen receptor (ER) degradation inducer that induces CIAP1-mediated ERα ubiquitination, leading to its proteasome degradation.
	BPL-200931	(αS,βR)-β-Amino-α-hydroxy-N-[(1S)-1-[[[7-[[2-[4-[(1Z)-1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]methylamino]-7-oxoheptyl]amino]carbonyl]-3-methylbutyl]benzenebutanamide	1428546-76-2	cIAP1	ER	Inquiry
Molecular Weight: 791.05 Molecular Formula: C48H62N4O6 Boiling Point: 983.2±65.0°C at 760 Torr Density: 1.144±0.06 g/cm3 Description: It is an estrogen receptor (ER) degradation inducer that induces CIAP1-mediated ERα ubiquitination, leading to its proteasome degradation.
	BPL-200932	SNIPER(ER)-89	2095244-84-9	XIAP	ER	Inquiry
Molecular Weight: 1000.27 Molecular Formula: C57H69N5O9S Boiling Point: 1079.6±65.0°C at 760 Torr Density: 1.214±0.06 g/cm3 Description: It reduces ERα levels in tumor xenografts and inhibits the growth of ERα-positive breast tumors in mice. It preferentially recruits X-linked IAP (XIAP) to degrade ERα via the ubiquitin-proteasome pathway.