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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
5-((2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200873 5-((2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 865.32

Molecular Formula: C44H42ClFN8O8

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
5-((3-(4-(3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)propyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200874 5-((3-(4-(3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)propyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 917.44

Molecular Formula: C48H50ClFN10O6

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
GMB-101 BPL-200875 GMB-101 2489876-12-0

VHL

BCR-ABL

 Inquiry

Molecular Weight: 888.97

Molecular Formula: C44H47F3N8O7S

Boiling Point: 1075.6±65.0°C at 760 Torr

Density: 1.345±0.06 g/cm3

Description: It is a PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.
GMB-180 BPL-200876 GMB-180 2489876-19-7

VHL

BCR-ABL

 Inquiry

Molecular Weight: 861.94

Molecular Formula: C43H46F3N7O7S

Boiling Point: 1025.8±65.0°C at 760 Torr

Density: 1.337±0.06 g/cm3

Description: It is a PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.
(2S,4R)-1-((2S)-2-(tert-Butyl)-17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4,14-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-200877 (2S,4R)-1-((2S)-2-(tert-Butyl)-17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4,14-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2247480-68-6

VHL

CRBN

 Inquiry

Molecular Weight: 933.05

Molecular Formula: C45H56N8O12S

Boiling Point: 1207.0±65.0°C at 760 Torr

Density: 1.368±0.06 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N14-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12-tetraoxatetradecanediamide BPL-200878 N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N14-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12-tetraoxatetradecanediamide 2358775-74-1

VHL

CRBN

 Inquiry

Molecular Weight: 977.11

Molecular Formula: C47H60N8O13S

Boiling Point: 1221.2±65.0°C at 760 Torr

Density: 1.355±0.06 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N17-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15-pentaoxaheptadecanediamide BPL-200879 N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N17-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15-pentaoxaheptadecanediamide 2247480-67-5

VHL

CRBN

 Inquiry

Molecular Weight: 1021.16

Molecular Formula: C49H64N8O14S

Boiling Point: 1235.8±65.0°C at 760 Torr

Density: 1.342±0.06 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide BPL-200880 N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide 2358775-72-9

VHL

CRBN

 Inquiry

Molecular Weight: 1065.21

Molecular Formula: C51H68N8O15S

Boiling Point: 1250.8±65.0°C at 760 Torr

Density: 1.331±0.06 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N29-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18,21,24,27-nonaoxanonacosanediamide BPL-200881 N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N29-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18,21,24,27-nonaoxanonacosanediamide 2358775-73-0

VHL

CRBN

 Inquiry

Molecular Weight: 1197.37

Molecular Formula: C57H80N8O18S

Boiling Point: 1290.9±65.0°C at 760 Torr

Density: 1.304±0.06 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
(2S,4R)-1-((2S)-2-(tert-Butyl)-18-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4,15-dioxo-6,13-dioxa-3,16-diazaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-200882 (2S,4R)-1-((2S)-2-(tert-Butyl)-18-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4,15-dioxo-6,13-dioxa-3,16-diazaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2358775-71-8

VHL

CRBN

 Inquiry

Molecular Weight: 945.11

Molecular Formula: C47H60N8O11S

Boiling Point: 1202.3±65.0°C at 760 Torr

Density: 1.334±0.06 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
(2S,4R)-N-(2-((1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide BPL-200883 (2S,4R)-N-(2-((1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide 2358775-78-5

VHL

CRBN

 Inquiry

Molecular Weight: 1021.14

Molecular Formula: C49H61FN8O13S

Boiling Point: 1235.1±65.0°C at 760 Torr

Density: 1.42±0.1 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
(2S,4R)-N-(2-((1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosan-20-yl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide BPL-200884 (2S,4R)-N-(2-((1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosan-20-yl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide 2358775-79-6

VHL

CRBN

 Inquiry

Molecular Weight: 1109.24

Molecular Formula: C53H69FN8O15S

Boiling Point: 1264.7±65.0°C at 760 Torr

Density: 1.40±0.1 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
(2S,4R)-N-(2-((5-((2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-5-oxopentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide BPL-200885 (2S,4R)-N-(2-((5-((2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-5-oxopentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide 2358775-80-9

VHL

CRBN

 Inquiry

Molecular Weight: 931.06

Molecular Formula: C46H55FN8O10S

Boiling Point: 1206.1±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
(2S,4R)-1-((17R)-1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-17-(1-fluorocyclopropane-1-carboxamido)-16,16-dimethyl-4-oxo-6,9,12-trioxa-15-thia-3-azaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-200886 (2S,4R)-1-((17R)-1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-17-(1-fluorocyclopropane-1-carboxamido)-16,16-dimethyl-4-oxo-6,9,12-trioxa-15-thia-3-azaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2358775-85-4

VHL

CRBN

 Inquiry

Molecular Weight: 1023.18

Molecular Formula: C48H59FN8O12S2

Boiling Point: 1257.1±65.0°C at 760 Torr

Density: 1.44±0.1 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
(2S,4R)-1-((23R)-1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-23-(1-fluorocyclopropane-1-carboxamido)-22,22-dimethyl-4-oxo-6,9,12,15,18-pentaoxa-21-thia-3-azatetracosan-24-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-200887 (2S,4R)-1-((23R)-1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-23-(1-fluorocyclopropane-1-carboxamido)-22,22-dimethyl-4-oxo-6,9,12,15,18-pentaoxa-21-thia-3-azatetracosan-24-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2358775-86-5

VHL

CRBN

 Inquiry

Molecular Weight: 1111.28

Molecular Formula: C52H67FN8O14S2

Boiling Point: 1284.9±65.0°C at 760 Torr

Density: 1.42±0.1 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
(2S,4R)-1-((2R)-3-((5-((2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-5-oxopentyl)thio)-2-(1-fluorocyclopropane-1-carboxamido)-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-200888 (2S,4R)-1-((2R)-3-((5-((2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-5-oxopentyl)thio)-2-(1-fluorocyclopropane-1-carboxamido)-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2358775-87-6

VHL

CRBN

 Inquiry

Molecular Weight: 933.10

Molecular Formula: C45H53FN8O9S2

Boiling Point: 1225.3±65.0°C at 760 Torr

Density: 1.45±0.1 g/cm3

Description: It is a VHL-CRBN hetero-dimerizing PROTAC.
P13IS BPL-200889 P13IS 2360561-69-7

CRBN

BTK

 Inquiry

Molecular Weight: 910.99

Molecular Formula: C47H50N12O8

Density: 1.49±0.1 g/cm3

Description: It efficiently knocks down Bruton's tyrosine kinase (BTK) protein globally in vivo.
(S)-7-(2-(2-(2-(2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinolin-7-yl)oxy)ethoxy)ethoxy)ethoxy)ethoxy)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide BPL-200890 (S)-7-(2-(2-(2-(2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinolin-7-yl)oxy)ethoxy)ethoxy)ethoxy)ethoxy)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 2027561-96-0

cIAP1

RIPK2

 Inquiry

Molecular Weight: 1092.40

Molecular Formula: C58H73N7O10S2

Boiling Point: 1202.4±65.0°C at 760 Torr

Density: 1.31±0.1 g/cm3

Description: It is a PROTAC that selectively degrades receptor interacting Serine/threonine protein kinase 2 (RIPK2).
(S)-16-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-17,17-dimethyl-5,14-dioxo-8,11-dioxa-4,15-diazaoctadecyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate BPL-200891 (S)-16-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-17,17-dimethyl-5,14-dioxo-8,11-dioxa-4,15-diazaoctadecyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate 2509359-66-2

VHL

Cdc20

 Inquiry

Molecular Weight: 943.35

Molecular Formula: C40H54Cl3N9O9S

Density: 1.362±0.06 g/cm3

Description: It deprives the mitotic role for Cdc20-APC/C by either inhibition of Cdc20-APC/C activity or elimination of Cdc20 protein via induced protein degradation.
(S)-19-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-5,17-dioxo-8,11,14-trioxa-4,18-diazahenicosyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate BPL-200892 (S)-19-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-5,17-dioxo-8,11,14-trioxa-4,18-diazahenicosyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate 2509359-69-5

VHL

Cdc20

 Inquiry

Molecular Weight: 987.41

Molecular Formula: C42H58Cl3N9O10S

Density: 1.349±0.06 g/cm3

Description: It deprives the mitotic role for Cdc20-APC/C by either inhibition of Cdc20-APC/C activity or elimination of Cdc20 protein via induced protein degradation.

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