PROTAC Library

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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
DAT12 BPL-200853 DAT12

VHL

SGK3

 Inquiry

Molecular Weight: 1215.94

Molecular Formula: C60H79ClN10O11S2

Description: It is an isoform-specific SGK3 kinase PROTAC degrader.
UNC6851 BPL-200854 UNC6851 2688842-07-9

VHL

EED
EZH2
SUZ12

 Inquiry

Molecular Weight: 818.96

Molecular Formula: C42H46N10O6S

Density: 1.42±0.1 g/cm3

Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
UNC6853 BPL-200855 UNC6853 2688842-09-1

VHL

EED
EZH2
SUZ12

 Inquiry

Molecular Weight: 847.02

Molecular Formula: C44H50N10O6S

Density: 1.39±0.1 g/cm3

Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
UNC6845 BPL-200856 UNC6845 2688842-10-4

VHL

EED
EZH2
SUZ12

 Inquiry

Molecular Weight: 907.07

Molecular Formula: C46H54N10O8S

Density: 1.39±0.1 g/cm3

Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
UNC6846 BPL-200857 UNC6846 2688842-11-5

VHL

EED
EZH2
SUZ12

 Inquiry

Molecular Weight: 937.09

Molecular Formula: C47H56N10O9S

Density: 1.38±0.1 g/cm3

Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
UNC6847 BPL-200858 UNC6847 2688842-12-6

VHL

EED
EZH2
SUZ12

 Inquiry

Molecular Weight: 995.17

Molecular Formula: C50H62N10O10S

Density: 1.36±0.1 g/cm3

Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)propanamide BPL-200859 3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)propanamide

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 936.40

Molecular Formula: C47H47ClFN9O9

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)propanamide BPL-200860 3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)propanamide

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 1024.50

Molecular Formula: C51H55ClFN9O11

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
3-(2-(2-((4-(3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)propyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide BPL-200861 3-(2-(2-((4-(3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)propyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 1018.50

Molecular Formula: C51H53ClFN11O9

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
3-(2-(2-((4-(2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide BPL-200862 3-(2-(2-((4-(2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 1136.64

Molecular Formula: C56H63ClFN11O12

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-(2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200863 4-(2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 910.36

Molecular Formula: C46H45ClFN7O10

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-((14-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200864 4-((14-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 954.41

Molecular Formula: C48H49ClFN7O11

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-((17-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200865 4-((17-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 998.46

Molecular Formula: C50H53ClFN7O12

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-((2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200866 4-((2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 909.37

Molecular Formula: C46H46ClFN8O9

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-((12-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)dodecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200867 4-((12-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)dodecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 917.48

Molecular Formula: C50H54ClFN8O6

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-((3-((3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)propyl)(methyl)amino)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200868 4-((3-((3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)propyl)(methyl)amino)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 862.36

Molecular Formula: C45H45ClFN9O6

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-((2-(4-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethyl)piperazin-1-yl)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200869 4-((2-(4-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethyl)piperazin-1-yl)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 889.39

Molecular Formula: C46H46ClFN10O6

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
XY-4-88 BPL-200870 XY-4-88

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 917.44

Molecular Formula: C48H50ClFN10O6

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-((4-(4-(4-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)butyl)piperazin-1-yl)butyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200871 4-((4-(4-(4-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)butyl)piperazin-1-yl)butyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 945.50

Molecular Formula: C50H54ClFN10O6

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
4-((2-(2-(4-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethyl)piperazin-1-yl)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione BPL-200872 4-((2-(2-(4-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethyl)piperazin-1-yl)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CRBN

KRAS G12C

 Inquiry

Molecular Weight: 977.50

Molecular Formula: C50H54ClFN10O8

Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.

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