PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-200853	DAT12		VHL	SGK3	Inquiry
Molecular Weight: 1215.94 Molecular Formula: C60H79ClN10O11S2 Description: It is an isoform-specific SGK3 kinase PROTAC degrader.
	BPL-200854	UNC6851	2688842-07-9	VHL	EED EZH2 SUZ12	Inquiry
Molecular Weight: 818.96 Molecular Formula: C42H46N10O6S Density: 1.42±0.1 g/cm3 Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
	BPL-200855	UNC6853	2688842-09-1	VHL	EED EZH2 SUZ12	Inquiry
Molecular Weight: 847.02 Molecular Formula: C44H50N10O6S Density: 1.39±0.1 g/cm3 Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
	BPL-200856	UNC6845	2688842-10-4	VHL	EED EZH2 SUZ12	Inquiry
Molecular Weight: 907.07 Molecular Formula: C46H54N10O8S Density: 1.39±0.1 g/cm3 Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
	BPL-200857	UNC6846	2688842-11-5	VHL	EED EZH2 SUZ12	Inquiry
Molecular Weight: 937.09 Molecular Formula: C47H56N10O9S Density: 1.38±0.1 g/cm3 Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
	BPL-200858	UNC6847	2688842-12-6	VHL	EED EZH2 SUZ12	Inquiry
Molecular Weight: 995.17 Molecular Formula: C50H62N10O10S Density: 1.36±0.1 g/cm3 Description: It is an EED-targeted bivalent chemical degrader that targets polycomb repressive complex 2 (PRC2).
	BPL-200859	3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)propanamide		CRBN	KRAS G12C	Inquiry
Molecular Weight: 936.40 Molecular Formula: C47H47ClFN9O9 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200860	3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecyl)propanamide		CRBN	KRAS G12C	Inquiry
Molecular Weight: 1024.50 Molecular Formula: C51H55ClFN9O11 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200861	3-(2-(2-((4-(3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)propyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide		CRBN	KRAS G12C	Inquiry
Molecular Weight: 1018.50 Molecular Formula: C51H53ClFN11O9 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200862	3-(2-(2-((4-(2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-1-yl)methoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamide		CRBN	KRAS G12C	Inquiry
Molecular Weight: 1136.64 Molecular Formula: C56H63ClFN11O12 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200863	4-(2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 910.36 Molecular Formula: C46H45ClFN7O10 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200864	4-((14-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 954.41 Molecular Formula: C48H49ClFN7O11 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200865	4-((17-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 998.46 Molecular Formula: C50H53ClFN7O12 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200866	4-((2-(2-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 909.37 Molecular Formula: C46H46ClFN8O9 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200867	4-((12-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)dodecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 917.48 Molecular Formula: C50H54ClFN8O6 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200868	4-((3-((3-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)propyl)(methyl)amino)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 862.36 Molecular Formula: C45H45ClFN9O6 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200869	4-((2-(4-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethyl)piperazin-1-yl)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 889.39 Molecular Formula: C46H46ClFN10O6 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200870	XY-4-88		CRBN	KRAS G12C	Inquiry
Molecular Weight: 917.44 Molecular Formula: C48H50ClFN10O6 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200871	4-((4-(4-(4-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)butyl)piperazin-1-yl)butyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 945.50 Molecular Formula: C50H54ClFN10O6 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.
	BPL-200872	4-((2-(2-(4-(2-(2-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)ethoxy)ethyl)piperazin-1-yl)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione		CRBN	KRAS G12C	Inquiry
Molecular Weight: 977.50 Molecular Formula: C50H54ClFN10O8 Description: It is a C12-directed covalent degrader molecule (PROTAC) that successfully binds to CRBN in cells, binds to KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in a CRBN dependent manner.