Benzyl-PEG2-ethoxyethane-PEG2
CAS No.: 2115897-18-0
Cat No.: BP-500327
4.5 
Benzyl-PEG2-ethoxyethane-PEG2 is a polyethylene glycol (PEG)-based bifunctional linker featuring a benzyl terminus connected through short PEG segments to an ethoxyethane spacer, providing a flexible, hydrophilic chain architecture. The two PEG2 regions act as solubilizing and spacing elements, while the ethoxyethane segment contributes conformational mobility that can reduce steric interference between the two conjugated partners. In PROTAC design, such PEG/ether linkers are commonly used to connect a target-binding ligand to an E3 ligase-recruiting moiety, helping to position the warhead and ligase-binding groups within productive proximity for ternary complex formation. The benzyl end can serve as a convenient attachment handle depending on the functionalization strategy of the overall construct. This linker is valuable for targeted protein degradation research where improved aqueous compatibility, tunable linker length, and minimized steric constraints can enhance degradation efficiency and experimental robustness during iterative PROTAC optimization.
Structure of 2115897-18-0
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This PEG-based linker is designed to support efficient assembly of PROTAC constructs by providing a flexible, hydrophilic spacer between the target-binding and E3-ligase-binding modules. Its ether-rich architecture helps maintain conformational freedom, which can improve productive ternary complex formation and degradation performance. The following sections describe the linker’s structural features and practical reactivity considerations for PROTAC synthesis in detail.
Structure: Benzyl-PEG2-ethoxyethane-PEG2 is an ether-containing, polyethylene glycol-derived linker featuring multiple oxygen atoms that confer strong hydrogen-bonding capacity and water compatibility. It presents an aromatic benzyl terminus connected through an ether linkage, with flexible C–O–C segments and terminal functional groups suitable for bioconjugation-style coupling.
Reactivity: Linkers of this PEG-ether type are commonly incorporated into PROTACs via standard amide-forming or ether/alkylation coupling strategies, depending on the functional handles present on the attachment sites. Typical approaches use nucleophilic substitution or acyl-transfer chemistry under inert or mildly basic conditions, often employing coupling reagents and polar aprotic solvents to promote selective bond formation while minimizing PEG chain scrambling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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