DBCO-PEG8-acid
Cat No.: BP-501830
4.5 
DBCO-PEG8-acid is a heterobifunctional PEG-based linker bearing a dibenzocyclooctyne (DBCO) group and a terminal carboxylic acid. Structurally, it consists of a DBCO moiety connected through an eight-unit polyethylene glycol chain to a free carboxyl group, providing both a bioorthogonal handle for strain-promoted azide–alkyne cycloaddition (SPAAC) and an acid functionality for covalent attachment to amines or other nucleophiles via standard coupling chemistries. In PROTAC and targeted degradation workflows, this linker is used to conjugate and spatially tune components: the DBCO enables rapid, catalyst-free ligation to azide-functional ligands (e.g., E3 ligase recruiters or targeting ligands), while the PEG spacer improves solubility and reduces steric interference at the ternary-complex interface. Its value lies in facilitating modular assembly of degradation constructs under mild conditions, supporting systematic optimization of linker length and attachment geometry to improve degradation efficiency and experimental reproducibility.
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* For research and manufacturing use only. Not for human or clinical use.
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DBCO-PEG8-acid is a bifunctional polyethylene glycol–based PROTAC linker that enables efficient conjugation of ligands through strain-promoted azide–alkyne cycloaddition (SPAAC) while providing a carboxylic acid handle for subsequent coupling to targeting modules. Its PEG spacer supports favorable solubility and conformational flexibility, which can improve productive ternary complex formation in targeted protein degradation workflows. The structure and reactivity considerations for constructing PROTACs with this linker are described in detail below.
Structure: The linker contains a DBCO (dibenzocyclooctyne) cyclooctyne moiety for SPAAC reactivity, connected to a PEG chain that provides a hydrophilic, flexible spacer, terminating in a carboxylic acid group. It features ether linkages within PEG and an alkyne-bearing cyclooctyne for strain-activated cycloaddition.
Reactivity: PROTAC assembly using this linker typically relies on SPAAC between the DBCO group and an azide-functional ligand under mild, catalyst-free conditions, preserving sensitive biomolecule conjugates. The terminal carboxylic acid is commonly activated for amide or ester bond formation using standard coupling chemistries (e.g., carbodiimide-based systems with appropriate additives) in polar aprotic or mixed aqueous/organic solvents. Reaction design should consider solvent compatibility and maintaining azide/DBCO integrity to drive efficient conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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