Biotin-PEG6-alcohol
CAS No.: 906099-89-6
Cat No.: BP-501132
Purity: >97%
4.5 
Biotin-PEG6-alcohol is a polyethylene glycol (PEG)–based linker terminating in an alcohol and bearing a biotin moiety for high-affinity capture by streptavidin or avidin. The PEG6 chain provides aqueous solubility, conformational flexibility, and a hydrophilic spacer that can reduce steric interference between the biotin handle and the functional groups on the conjugated partners. In PROTAC and targeted protein degradation workflows, this linker is valuable as a modular attachment element: the biotin enables affinity purification, immobilized assays, and controlled presentation of a PROTAC or its components on streptavidin-coated surfaces, facilitating binding/ternary-complex studies and downstream analysis. Its flexible, non-cleavable PEG scaffold supports conjugation strategies where maintaining accessibility of both the targeting ligand and the recruited-protein moiety is critical. Overall, it helps researchers streamline synthesis and characterization of biotin-tagged degraders and related targeted degradation intermediates.
Structure of 906099-89-6
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Biotin-PEG6-alcohol is a PEG-based linker designed to integrate biotin handles into PROTAC architectures, supporting modular assembly of bifunctional degraders. Its flexible poly(ethylene glycol) segment helps tune solubility and spatial presentation of functional groups, while the alcohol functionality enables straightforward conjugation strategies. This product is well suited for constructing targeted protein degradation tools where reliable attachment chemistry and favorable linker dynamics are important. Detailed structural and reactivity considerations are provided below.
Structure: Biotin-PEG6-alcohol consists of a biotin moiety connected to a flexible poly(ethylene glycol) chain terminated by a primary alcohol. The linker contains ether linkages within the PEG segment and carbon–oxygen bonds at the terminal alcohol, providing a hydrophilic, conformationally mobile scaffold.
Reactivity: The terminal alcohol enables common PROTAC linker coupling routes such as ester formation, etherification, or conversion to activated intermediates for nucleophilic substitution. Typical approaches use alcohol-derivatization reagents under controlled pH and temperature, often with coupling catalysts or base to promote formation of reactive leaving groups. Suitable solvents include polar aprotic or alcohol-compatible media, selected to maintain PEG solubility and minimize side reactions, consistent with standard bioconjugation practices.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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