Biotin-PEG3-CH2COOH
CAS No.: 1189560-96-0
Cat No.: BP-500574
4.5 
Biotin-PEG3-CH2COOH is a biotinylated polyethylene glycol linker bearing a terminal carboxymethyl group, providing a short, flexible hydrophilic spacer between a biotin moiety and a reactive handle. Structurally, it combines the high-affinity biotin–(strept)avidin recognition element with a three-unit PEG chain that reduces steric interference and improves aqueous solubility, while the carboxylic acid enables downstream conjugation through standard coupling chemistries (e.g., amide or ester formation after activation). In PROTAC and targeted degradation workflows, this linker is useful for modular assembly and immobilization: the biotin tag can be used to tether PROTAC components or intermediates to streptavidin-coated surfaces or carriers, facilitating controlled proximity, purification, or assay formats, whereas the terminal acid supports attachment to ligands or scaffold fragments. Its compact PEG architecture helps maintain productive geometry for ternary-complex formation and supports reproducible experimental handling in targeted protein degradation research.
Structure of 1189560-96-0
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Biotin-PEG3-CH2COOH is a polyethylene glycol-based PROTAC linker designed to connect targeting ligands to E3-recruiting or protein-binding modules while providing water-compatible flexibility. Its PEG segment helps tune solubility and conformational freedom, supporting efficient ternary complex formation in targeted protein degradation workflows. The carboxymethyl terminus offers a chemically addressable handle for conjugation strategies, enabling robust assembly of modular PROTAC constructs. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG chain terminated with a biotin moiety and a carboxymethyl group. It contains repeating ether linkages that confer hydrophilicity and conformational flexibility, along with ester/amide-forming functional groups at the terminus depending on derivatization. Overall, it behaves as a polar, water-compatible scaffold.
Reactivity: The terminal carboxylic acid is suited for standard PROTAC conjugation chemistry, including activation to form an acyl intermediate followed by nucleophilic substitution with amines or other nucleophiles on partner ligands. Common approaches use carbodiimide coupling systems and, when needed, auxiliary coupling reagents to improve efficiency. Reactions are typically performed under controlled pH in polar aprotic or mixed aqueous/organic solvents, minimizing PEG-related side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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