DOTA-PEG5-amine
Cat No.: BP-501843
Purity: 98%
4.5 
DOTA-PEG5-amine is a bifunctional polyethylene glycol (PEG) linker bearing a terminal primary amine and the macrocyclic chelator DOTA (1,4,7,10-tetraazacyclododecane tetraacetic acid). Structurally, it combines a multidentate metal-binding core with a flexible, water-solubilizing PEG chain of intermediate length, enabling stable conjugation chemistry to biomolecules and controlled spatial presentation of the chelator. In PROTAC and related targeted degradation constructs, such linkers are used to introduce a defined attachment handle for coupling to ligands or scaffolds while simultaneously providing a chelation site that can be exploited for imaging, tracking, or metal-coordinated experimental workflows that require proximity control. The PEG spacer helps reduce steric interference and can improve conjugate solubility, which is beneficial for maintaining productive ternary-complex formation when the overall architecture is optimized. This reagent is therefore valuable for researchers designing modular, conjugation-ready degradation tools and for experiments requiring robust chelator functionality.
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* For research and manufacturing use only. Not for human or clinical use.
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DOTA-PEG5-amine is a bifunctional PEG-based linker bearing a DOTA chelator and a terminal primary amine, designed to support modular PROTAC assembly and stable conjugation chemistry. Its flexible poly(ethylene glycol) segment can help tune linker length and solvation, while the DOTA motif provides a robust coordination scaffold for radiometal or metal-ion handling during research workflows. The detailed Structure and Reactivity parameters are provided below.
Structure: DOTA-PEG5-amine combines a macrocyclic chelator core with a flexible PEG chain terminated by a primary amine. The molecule contains multiple ether linkages within the PEG segment and carboxylate-bearing coordination functionality typical of DOTA, enabling strong metal binding and stable conjugation through the amine.
Reactivity: The terminal primary amine enables nucleophilic coupling to activated electrophiles commonly used in PROTAC synthesis, such as activated carboxylic acids (e.g., NHS/activated esters) or isocyanates, forming stable amide or urea linkages. Typical conditions use polar aprotic or aqueous-organic solvent systems under mild base or neutral pH to preserve DOTA integrity. DOTA-containing linkers are generally compatible with standard peptide-conjugation chemistries, while avoiding strongly chelating or oxidizing conditions that could perturb metal coordination.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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