Lipoamido-PEG3-alcohol
CAS No.: 1342764-64-0
Cat No.: BP-500799
Purity: ≥95%
4.5 
Lipoamido-PEG3-alcohol is a PEG-based linker building block featuring a terminal primary alcohol and an amide (“lipoamido”) functionality that can be used to introduce hydrophobic anchoring while maintaining aqueous solubility through a short three-unit ethylene glycol chain. In PROTAC and related targeted protein degradation constructs, such linkers are commonly employed to tune the physicochemical properties of the conjugate—balancing membrane/target engagement potential with solubility and minimizing nonspecific aggregation. The lipoamido handle provides a chemically addressable site for coupling to other PROTAC modules (for example, via amide-bond formation to a carboxyl-activated partner or through derivatization of the alcohol for subsequent attachment). The short PEG spacer helps control linker length and flexibility, which can influence ternary complex formation and degradation efficiency. This reagent is therefore valuable for systematic linker optimization in targeted degradation research, supporting reproducible synthesis of modular conjugates for structure–activity relationship studies.
Structure of 1342764-64-0
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Lipoamido-PEG3-alcohol is a PEG-based linker designed to connect targeting ligands in PROTAC architectures while providing conformational flexibility and improved solubility in common organic/aqueous workflows. Its lipoamide functionality supports robust, chemoselective coupling strategies, enabling efficient assembly of degraders that rely on proximity-driven ternary complex formation. The detailed structural and reactivity considerations for constructing PROTACs are provided below.
Structure: The linker comprises a flexible poly(ethylene glycol) chain terminating in an alcohol, coupled through an amide (lipoamide) linkage. It contains hydrogen-bonding heteroatoms, ether oxygen atoms, and an amide carbonyl, with polar, conformationally mobile segments that often enhance aqueous compatibility and reduce aggregation.
Reactivity: The terminal alcohol enables conversion to activated intermediates (for example, carbonate or ester derivatives) under standard coupling conditions, followed by nucleophilic substitution or amide/ester formation with complementary functional groups on PROTAC building blocks. Amide-based coupling is typically performed using carbodiimide or related activating reagents in polar solvents, with mild bases to promote nucleophile formation while preserving sensitive ligands.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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