m-PEG24-DSPE
Cat No.: BP-501747
4.5 
m-PEG24-DSPE is a methoxy-capped polyethylene glycol (PEG)–DSPE conjugate in which a DSPE phospholipid anchor is linked to a PEG chain of intermediate length, providing a flexible, hydrophilic spacer between the lipid headgroup and the terminal PEG region. Structurally, it combines the membrane-affinity and bilayer-forming characteristics of DSPE with PEG’s steric stabilization and aqueous solubility, yielding an amphiphilic construct with a defined linker architecture. In PROTAC and targeted degradation workflows, such PEG–lipid linkers are commonly used to organize or present reactive handles on nanoparticles or liposomes, thereby improving the effective local concentration of PROTAC components and supporting multivalent engagement of target-binding and E3-recruiting modules. This product is valuable for researchers developing delivery-compatible PROTAC formulations, where controlled surface hydration, reduced nonspecific interactions, and stable membrane association can enhance experimental reproducibility and enable systematic structure–function studies.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG24-DSPE is a PEGylated phospholipid linker designed to integrate hydrophilic polyethylene glycol spacers with a membrane-active DSPE headgroup, supporting the assembly and presentation of ligands in targeted protein degradation workflows. Its amphiphilic character can improve solubility and formulation flexibility for PROTAC-related conjugates, while the PEG segment helps modulate steric accessibility and local microenvironment around the binding moieties. The structure and reactivity considerations are described in detail below.
Structure: The linker combines a DSPE phospholipid scaffold with a polyethylene glycol chain, providing an amphiphilic architecture. It contains ester and ether linkages, a phosphodiester functionality, and a long, flexible PEG segment that confers conformational mobility and hydrophilicity.
Reactivity: DSPE-based phospholipids are commonly functionalized through derivatization strategies that target the PEG terminus or the lipid headgroup, enabling coupling to ligand-bearing handles used in PROTAC construction. Typical approaches rely on amide or ether-forming chemistries under mild, anhydrous or buffered conditions, with coupling reagents and bases selected according to the reactive groups present on the partner ligands. Solvents such as polar aprotic media or lipid-compatible systems are used to maintain amphiphile integrity and promote efficient conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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