Name: Mal-PEG3-PFP ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO

Storage

Store at 2-8°C

Shipping

Room temperature

IUPACName

(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]propanoate

Synonyms

Mal-PEG3-PFP; Perfluorophenyl 3-(2-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)ethoxy)propanoate; Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester

Boiling Point

531.5±50.0°C (Predicted)

Density

1.438±0.06 g/cm3 (Predicted)

InChI Key

NTHCDRJWHPEQDJ-UHFFFAOYSA-N

InChI

InChI=1S/C19H18F5NO7/c20-14-15(21)17(23)19(18(24)16(14)22)32-13(28)3-5-29-7-9-31-10-8-30-6-4-25-11(26)1-2-12(25)27/h1-2H,3-10H2

SMILES

C1=CC(=O)N(C1=O)CCOCCOCCOCCC(=O)OC2=C(C(=C(C(=C2F)F)F)F)F

Mal-PEG3-PFP ester is a heterobifunctional PEG-based linker designed to enable efficient conjugation of targeting ligands in PROTAC architectures. Its maleimide handle supports selective thiol coupling, while the activated PFP ester facilitates amide-bond formation with primary amines. This combination supports modular assembly, improved solubility, and streamlined synthesis of targeted protein degraders. Detailed structural and reactivity considerations are provided below.

Structure: The linker contains a maleimide moiety for Michael-type addition to thiols and a poly(ethylene glycol) segment that imparts hydrophilicity and flexible spacing. A pentafluorophenyl activated ester enables acyl-transfer chemistry, with ester and heteroaromatic functionalities governing reactivity and stability.

Reactivity: For PROTAC construction, the PFP ester is typically reacted with primary amines to form stable amide bonds under mild base conditions, often using polar aprotic or mixed aqueous buffers compatible with activated esters. The maleimide is then coupled to cysteine-containing ligands via thiol addition, favoring controlled pH and exclusion of competing thiols. Sequential conjugation strategies are commonly employed to preserve orthogonality.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂