Name: mPEG8-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO, Water

Appearance

Pale Yellow Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature

IUPACName

2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine

Synonyms

m-PEG8-amine; 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-amine; mPEG8-NH2; 3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine; 3,6,9,12,15,18,21,24-octaoxa-pentacosylamine; methyl-PEG8-amine

Boiling Point

448.0±40.0°C (Predicted)

Density

1.054±0.06 g/cm3 (Predicted)

InChI Key

YXWBFPPGROXJLL-UHFFFAOYSA-N

InChI

InChI=1S/C17H37NO8/c1-19-4-5-21-8-9-23-12-13-25-16-17-26-15-14-24-11-10-22-7-6-20-3-2-18/h2-18H2,1H3

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCN

Biological Activity

m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

mPEG8-amine is a polyethylene glycol–based amine linker designed to support the modular assembly of PROTACs and related targeted protein degradation constructs. Its hydrophilic PEG segment can improve solubility and bioconjugation compatibility while providing a reactive primary amine handle for coupling to ligands. The structure and reactivity considerations for experimental use are described in detail below.

Structure: The product comprises an mPEG chain terminated with a primary amine, featuring repeating ether linkages that confer flexibility and strong hydrogen-bonding/solvation behavior. The terminal C–N bond enables derivatization, while the ether-rich backbone provides chemical stability under typical peptide-conjugation conditions and reduces aggregation.

Reactivity: The primary amine enables standard PROTAC linker chemistry such as amide bond formation via activated carboxylic acids (e.g., NHS- or EDC-mediated coupling) and reductive amination with appropriate aldehydes or ketones. Reactions are commonly performed in polar aprotic or aqueous buffer systems with pH control to maintain amine nucleophilicity, using coupling reagents and optional base to drive amide formation.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂