mPEG8-amine

 CAS No.: 869718-81-0  Cat No.: BP-501160  Purity: ≥95% 4.5  

mPEG8-amine features a long PEG chain with an amine terminus, ideal for ADC linker synthesis. Its extended PEG8 spacer improves bioconjugate solubility, reduces aggregation, and enhances circulation stability in targeted drug delivery systems.

mPEG8-amine

Structure of 869718-81-0

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Category
PROTAC Linker
Molecular Formula
C17H37NO8
Molecular Weight
383.48
Appearance
Pale Yellow Oily Matter

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO, Water
Appearance
Pale Yellow Oily Matter
Storage
Store at 2-8°C
Shipping
Room temperature
IUPACName
2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Synonyms
m-PEG8-amine; 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-amine; mPEG8-NH2; 3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine; 3,6,9,12,15,18,21,24-octaoxa-pentacosylamine; methyl-PEG8-amine
Boiling Point
448.0±40.0°C (Predicted)
Density
1.054±0.06 g/cm3 (Predicted)
InChI Key
YXWBFPPGROXJLL-UHFFFAOYSA-N
InChI
InChI=1S/C17H37NO8/c1-19-4-5-21-8-9-23-12-13-25-16-17-26-15-14-24-11-10-22-7-6-20-3-2-18/h2-18H2,1H3
Canonical SMILES
COCCOCCOCCOCCOCCOCCOCCOCCN
Biological Activity
m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Historical Records: t-Butyl acetate-PEG3-CH2COOH | Mal-amido-PEG8-TFP ester | Boc-5-aminopentanoic NHS ester | Bromoacetyl-PEG3-DBCO | Azido-PEG7-t-butyl ester | mPEG10-azide | N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid | Mal-NH-PEG16-CH2CH2COOPFP ester | Mal-NH-PEG14-CH2CH2COOPFP ester | Boc-HyNic-PEG2-alkyne | mPEG8-amine

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