Ms-PEG12-m
CAS No.: 1059604-93-1
Cat No.: BP-500988
4.5 
Ms-PEG12-m is a methanesulfonyl-activated, heterobifunctional PEG linker designed for PROTAC and targeted protein degradation workflows requiring stable, efficient conjugation. Structurally, it comprises a linear polyethylene glycol chain of intermediate length terminated with a mesylate leaving group, enabling nucleophilic substitution by amine or thiol functionalities on a ligand or warhead while maintaining PEG-mediated solubility and reduced nonspecific interactions. In PROTAC assembly, the linker serves as a flexible spacer that positions the E3-recruiting ligand and the target-binding moiety to favor formation of the ternary complex, while the PEG segment can help mitigate steric mismatch and improve aqueous handling during synthesis and screening. This reagent is valuable for constructing degraders with tunable linker geometry and for streamlining late-stage coupling steps, supporting systematic structure–activity relationship studies in targeted degradation research.
Structure of 1059604-93-1
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This PROTAC linker reagent, designated Ms-PEG12-m, is a polyethylene glycol–based scaffold designed to provide solubility, conformational flexibility, and a reliable attachment handle for assembling targeted protein degraders. Its PEG character can help improve aqueous compatibility and linker-mediated spatial presentation between the ligand-binding and E3-recruiting modules. The details below describe its structural features and practical considerations for PROTAC construction and subsequent conjugation steps.
Structure: Ms-PEG12-m is a PEGylated linker featuring ether-rich repeating units that confer hydrophilicity and chain flexibility. It contains a functional group suitable for forming covalent connections to PROTAC components, with stable C–O and C–C frameworks and a polar, solvent-accessible backbone.
Reactivity: For PROTAC synthesis, the linker is typically used in coupling reactions that convert its reactive handle into a stable bond with a complementary functional group on the targeting or E3-binding ligand. Suitable conditions depend on the specific reactive group chemistry, commonly employing inert atmosphere or controlled pH, appropriate amine/acid-activation or nucleophile–electrophile pairing, and polar organic solvents to maintain solubility and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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