PEG12-Tos
CAS No.: 1050500-41-8
Cat No.: BP-501001
Purity: 98.0%
4.5 
PEG12-Tos is a polyethylene glycol–based linker bearing a tosyl (tosylate) leaving group, providing a hydrophilic, flexible chain that can be used to connect PROTAC components through controlled nucleophilic substitution. Structurally, the PEG segment offers conformational mobility and improves aqueous solubility, while the terminal tosyl group enables efficient coupling to amine or other nucleophiles commonly found in ligand handles, facilitating the installation of the linker between a target-binding ligand and an E3-recruiting moiety. In PROTAC design, such PEG linkers help tune the effective distance and relative orientation required for productive ternary complex formation, often reducing steric mismatch and improving degradation performance. For targeted protein degradation research, PEG12-Tos is valuable as a modular building block that supports systematic linker optimization, enabling researchers to rapidly generate conjugates for evaluating degradation potency, selectivity, and cellular activity.
Structure of 1050500-41-8
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This PEG-based linker, PEG12-Tos, is designed to support PROTAC assembly by providing a flexible, hydrophilic spacer that can improve solubility and reduce steric constraints between the target-binding and E3-recruiting modules. Its tosylate-derived functionality enables reliable synthetic coupling strategies commonly used in targeted protein degradation workflows. The sections below describe the linker’s structure and the practical considerations for PROTAC construction in detail.
Structure: PEG12-Tos is a polyethylene glycol linker bearing a tosylate (tosyl) leaving group, combining an ether-rich, flexible backbone with an activated sulfonate functionality. The molecule contains ether linkages and aromatic sulfonate bonding, promoting aqueous compatibility and conformational adaptability.
Reactivity: The tosylate group is suitable for nucleophilic substitution, allowing formation of ether or related linkages to connect PROTAC fragments under conditions compatible with PEG stability. Typical approaches use nucleophiles such as amines or alcohols, with base-mediated activation in polar aprotic or mixed solvents. Reaction proceeds via tosylate departure and nucleophile attack, often without requiring specialized catalysts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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