Name: Propargyl-PEG1-COOtBu
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

tert-butyl 3-prop-2-ynoxypropanoate

Synonyms

Propargyl-PEG1-t-butyl ester; Propargyl-PEG1-Boc; tert-butyl 3-(prop-2-ynyloxy)propanoate; 3-(2-Propyn-1-yloxy)propanoic acid tert-butyl ester

Boiling Point

239.2±15.0 °C at 760 mmHg

Density

1.0±0.1 g/cm3

InChI Key

VDHVLESCKRSEAF-UHFFFAOYSA-N

InChI

InChI=1S/C10H16O3/c1-5-7-12-8-6-9(11)13-10(2,3)4/h1H,6-8H2,2-4H3

SMILES

CC(C)(C)OC(=O)CCOCC#C

Propargyl-PEG1-COOtBu is a PEG-based PROTAC linker building block designed to connect an alkyne-bearing handle to a protected carboxylate functionality. Its ether-rich PEG segment supports conformational flexibility and aqueous compatibility, while the propargyl group enables efficient bioorthogonal coupling to partner ligands. The tert-butyl ester provides a convenient, stability-oriented protecting group that can be selectively removed when required. Detailed structural and reactivity considerations for PROTAC assembly are provided below.

Structure: The molecule contains a short poly(ethylene glycol) ether segment, a propargyl alkyne, and a tert-butyl ester-protected carboxylate. It features carbon–carbon triple-bond character, ether linkages, and an ester functional group, offering polarity and flexibility typical of PEG linkers used in targeted degradation constructs.

Reactivity: The propargyl alkyne is suitable for click-type conjugation strategies (commonly copper-catalyzed azide–alkyne cycloaddition or related alkyne coupling approaches) to join PROTAC fragments. The tert-butyl ester can be deprotected under standard acid-promoted conditions to regenerate a carboxylic acid for subsequent amide or ester formation. Typical coupling steps use activated carboxylate chemistry with appropriate bases and coupling reagents, selected to preserve the alkyne and PEG ether integrity.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂