Amino-PEG7-propionic acid
CAS No.: 2376111-92-9
Cat No.: BP-500562
Purity: ≥95%
4.5 
Amino-PEG7-propionic acid is a heterobifunctional PEG-based linker featuring a terminal primary amine and a terminal carboxylic acid separated by a polyethylene glycol chain of intermediate length, terminated with a propionic-acid motif. The flexible PEG backbone provides water solubility and conformational freedom, while the amine and carboxyl groups enable straightforward coupling chemistries (for example, amide bond formation with activated carboxylic acids or NHS/EDC-type coupling, and orthogonal functionalization when paired with other reactive handles). In PROTAC and targeted protein degradation workflows, such linkers are used to connect a ligand for an E3 ligase to a ligand for the target protein, tuning the spatial arrangement and effective reach of the two binding domains to promote productive ternary complex formation. Its balanced length and hydrophilicity make it valuable for optimizing degrader potency and selectivity in experimental series where linker length and attachment geometry are key determinants of degradation efficiency.
Structure of 2376111-92-9
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Amino-PEG7-propionic acid is a PEG-based PROTAC linker building block designed to provide hydrophilic spacing between a ligand-binding warhead and an E3-recruiting element. Its ether-rich poly(ethylene glycol) character supports favorable solubility and conformational flexibility, which can help maintain productive ternary complex formation. The amino handle enables straightforward conjugation to reactive partners, while the terminal carboxylic acid supports controlled amide coupling. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains a poly(ethylene glycol) chain featuring repeating ether linkages, terminating in a primary amino group and a carboxylic acid (propionic acid motif). It presents polar functional groups suitable for salt formation and hydrogen bonding, with an overall flexible, solvated scaffold that can reduce steric constraints in conjugates.
Reactivity: The primary amino and carboxylic acid enable standard bioconjugation chemistries used in PROTAC synthesis, most commonly amide bond formation via coupling reagents under mild, aqueous-organic conditions. Typical approaches include activating the carboxyl group (for example, with carbodiimide-based systems and additives) followed by nucleophilic attack from an amine-bearing partner. Alternatively, the amino group can be used for NHS-ester or activated-carboxyl intermediates, proceeding through well-established acyl substitution mechanisms.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
