Azido-PEG3-Sulfone-PEG4-acid
CAS No.: 2055024-42-3
Cat No.: BP-500958
Purity: 98%
4.5 
Azido-PEG3-Sulfone-PEG4-acid is a heterobifunctional, polyethylene glycol–based PROTAC linker featuring an azide handle for bioorthogonal conjugation, a sulfone-centered PEG spacer, and a terminal carboxylic acid for coupling to a ligand or reactive warhead. The PEG3 and PEG4 segments provide aqueous solubility and conformational flexibility, while the sulfone unit contributes chemical stability and a defined linkage region between the two PEG domains. In targeted protein degradation workflows, the azide group enables efficient attachment to complementary alkyne-containing partners via copper-free click chemistry, allowing modular assembly of PROTACs with controlled geometry. The terminal acid can be used to form amide or related linkages to install the degradation-recruiting ligand or targeting moiety, facilitating systematic variation of linker length and polarity. This linker is valuable for researchers seeking reproducible conjugation chemistry and tunable physicochemical properties to optimize ternary complex formation and cellular degradation efficacy.
Structure of 2055024-42-3
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG3-Sulfone-PEG4-acid, is designed to provide a flexible, water-compatible spacer that can connect targeting ligands to E3-recruiting modules while maintaining conformational freedom for productive ternary complex formation. Its multifunctional termini enable robust synthetic handle placement and subsequent coupling strategies commonly used in targeted protein degradation workflows. The
Structure: The linker comprises polyethylene glycol segments separated by a sulfone unit, offering a polar, flexible scaffold with ether-rich connectivity. An azide functional group provides a bioorthogonal reactive handle, while a terminal carboxylic acid enables amide or ester formation. The overall architecture supports solubility and reduced steric bias.
Reactivity: The azide group is suitable for click-type conjugations, including copper-catalyzed azide–alkyne cycloaddition or copper-free azide–alkyne variants, typically performed under inert or controlled atmospheres with compatible solvent systems to preserve sensitive ligands. The terminal carboxylic acid supports standard acyl coupling to install amide linkages using coupling reagents and base in common organic solvents. The sulfone and PEG ether framework generally remain stable under these conditions, facilitating stepwise PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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