Biotin-PEG11-amine
CAS No.: 1418022-42-0
Cat No.: BP-500436
4.5 
Biotin-PEG11-amine is a biotinylated polyethylene glycol linker featuring an amine terminus, providing a flexible, hydrophilic spacer between a biotin recognition element and a reactive conjugation handle. Structurally, it consists of a biotin moiety connected through an extended PEG chain of approximately eleven ethylene glycol units, with the distal primary amine enabling amide coupling, carbodiimide-mediated conjugation, or incorporation into PROTAC-related constructs. In targeted degradation design, such linkers are valuable for positioning a biotin-tagged module to engage streptavidin or biotin-binding domains, thereby facilitating controlled assembly of multicomponent systems and reliable spatial presentation of ligands. The PEG segment reduces nonspecific hydrophobic interactions and helps maintain productive geometry for ternary complex formation when biotin-mediated recruitment is used. This product is therefore useful for constructing and optimizing experimental PROTAC architectures, surface immobilization strategies, and assay formats that require robust biotin–streptavidin connectivity.
Structure of 1418022-42-0
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Biotin-PEG11-amine is a polyethylene glycol (PEG)-based linker bearing a terminal primary amine and a biotin handle, enabling modular conjugation in targeted protein degradation workflows. Its flexible, hydrophilic PEG segment can improve solubility and reduce steric constraints between binding and E3-recruiting elements, while the amine provides a practical attachment point for assembling PROTACs. The biotin motif further supports affinity-based handling and characterization of conjugates. Detailed structural and synthetic considerations are provided below.
Structure: The linker consists of a biotin moiety connected to a long PEG chain terminated by a primary amine. It features ether linkages within the PEG backbone, an amide-free terminal amine functionality, and heteroatom-rich regions that promote water compatibility. Overall, it is a flexible, polar conjugation scaffold.
Reactivity: The terminal primary amine is suitable for coupling reactions commonly used in PROTAC synthesis, including amide bond formation with activated carboxylic acids and urea/amide formation via carbodiimide-type coupling strategies. Typical approaches employ anhydrous or buffered organic solvents with controlled pH to maintain amine reactivity and minimize side reactions. Reaction conditions are selected to preserve PEG integrity and biotin stability, and purification is often performed to remove coupling reagents and byproducts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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