Biotin-PEG2-OH
CAS No.: 717119-80-7
Cat No.: BP-501716
4.5 
Biotin-PEG2-OH is a heterobifunctional PEG-based linker featuring a biotin moiety conjugated to a short polyethylene glycol chain terminating in a hydroxyl functionality, providing a flexible, hydrophilic spacer between biomolecular recognition and downstream coupling sites. In PROTAC and related targeted degradation workflows, this type of linker is used to incorporate a biotin handle that can enable affinity capture, immobilization, or controlled presentation of the PROTAC or its intermediates on streptavidin-coated surfaces, beads, or assay formats. The PEG segment reduces steric interference and helps maintain productive engagement between the ligand-binding domains of a degrader construct and the recruited E3 ligase machinery. Its short, flexible architecture is particularly useful when researchers need reliable tethering for binding/ternary complex assays, purification of conjugates, or mechanistic studies of degradation efficiency, while preserving solubility and minimizing nonspecific aggregation.
Structure of 717119-80-7
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Biotin-PEG2-OH is a polyethylene glycol-based linker designed to support PROTAC architectures that incorporate biotin-tagged recognition elements. Its hydrophilic PEG segment improves solubility and can help tune linker flexibility, while the terminal alcohol provides a convenient functional handle for downstream conjugation to ligands or warheads. The biotin motif enables compatibility with biotin-binding systems commonly used in targeted degradation workflows, and the following sections describe its structure and practical reactivity for PROTAC construction.
Structure: Biotin-PEG2-OH contains a biotin moiety connected through a short ethylene glycol repeat to a terminal hydroxyl group. The linker features ether linkages within the PEG chain, an alcohol at the terminus, and amide-containing biotin functionality, yielding a polar, water-compatible scaffold.
Reactivity: The terminal hydroxyl enables standard linker-functionalization reactions used to assemble PROTACs, such as activation to form an ester or ether for coupling to complementary electrophiles. Typical approaches rely on alcohol activation chemistry (for example, carbodiimide-mediated ester formation when paired with carboxylic acids, or acid-catalyzed/activated ester routes) under anhydrous, inert or controlled conditions, with polar aprotic solvents often used to maintain solubility and reaction efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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