Biotin-PEG7-azide
CAS No.: 1334172-75-6
Cat No.: BP-500706
4.5 
Biotin-PEG7-azide is a biotin-functionalized, polyethylene glycol (PEG) linker featuring an azide handle for bioorthogonal conjugation. Structurally, it combines a high-affinity biotin moiety with a seven-unit PEG spacer, providing aqueous solubility and a flexible, distance-controlling tether that can reduce steric interference when attached to proteins or other targeting ligands. In PROTAC and targeted-degradation workflows, this linker is valuable as a modular attachment reagent: the azide enables efficient coupling to complementary alkyne-bearing partners (e.g., via copper-free click chemistry) to install the linker onto degraders or accessory components, while biotin can be used to capture, immobilize, or track the conjugate using streptavidin-based systems. The PEG spacer helps maintain productive geometry for ternary-complex formation and facilitates downstream assay formats such as pull-downs, affinity enrichment, and fluorescence/biochemical readouts, supporting rigorous optimization of targeted protein degradation constructs.
Structure of 1334172-75-6
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Biotin-PEG7-azide is a polyethylene glycol-based PROTAC linker that combines a biotin handle with an azide functional group for efficient, modular conjugation. Its PEG segment provides conformational flexibility and improved solubility, supporting reliable linker presentation between targeting ligands and E3 ligase recruiters. The azide enables bioorthogonal “click” strategies commonly used in targeted protein degradation workflows, facilitating streamlined assembly of degraders.
Structure: The linker contains a PEG chain providing hydrophilic, flexible spacing, terminating in an azide group for selective conjugation. The biotin moiety introduces a rigid, high-affinity recognition element, while ether linkages and heteroatoms contribute to polarity and stable, non-covalent interactions in conjugate assemblies.
Reactivity: The azide functionality is well suited for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling rapid formation of triazole-linked PROTAC architectures. Typical conditions employ an appropriate alkyne partner, a compatible solvent system, and, for CuAAC, a copper catalyst with standard ligand/additive strategies to control reactivity and minimize side reactions. Reaction design should consider ligand solubility and stability under mild, aqueous-compatible conditions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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