Name: Biotin-PEG4-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>98%

Solubility

In DMSO: 100 mg/mL (216.17 mM; Need ultrasonic)

Appearance

White Waxy

Storage

Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]pentanamide

Synonyms

5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]pentanamide; 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]pentanamide

Boiling Point

724.4±60.0 °C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

GVGZXRGPGZMYTB-LNLFQRSKSA-N

InChI

InChI=1S/C20H38N4O6S/c21-5-7-27-9-11-29-13-14-30-12-10-28-8-6-22-18(25)4-2-1-3-17-19-16(15-31-17)23-20(26)24-19/h16-17,19H,1-15,21H2,(H,22,25)(H2,23,24,26)/t16-,17-,19-/m0/s1

SMILES

C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCOCCN)NC(=O)N2

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.1617 mL	10.8085 mL	21.6169 mL
5 mM	0.4323 mL	2.1617 mL	4.3234 mL
10 mM	0.2162 mL	1.0808 mL	2.1617 mL

Biotin-PEG4-amine is a polyethylene glycol (PEG) based linker reagent designed to couple biotin-containing ligands to PROTAC architectures while providing conformational flexibility and improved solubility. Its amine functionality enables straightforward formation of stable conjugates, supporting modular assembly of targeted protein degradation constructs. The linker’s hydrophilic PEG segment can help tune linker length and reduce nonspecific interactions. Detailed structural and reactivity considerations are provided below.

Structure: Biotin-PEG4-amine comprises a biotin moiety connected through an ether-linked PEG chain to a terminal primary amine. The structure features amide-compatible functional groups, multiple ether linkages, and a flexible, hydrophilic backbone that can reduce aggregation and promote aqueous compatibility.

Reactivity: The terminal primary amine is suitable for standard bioconjugation and PROTAC linker coupling strategies, including amide-bond formation with activated carboxylic acids or carboxylate derivatives, and nucleophilic substitution reactions with appropriately functionalized electrophiles. Typical workflows employ coupling reagents and base in polar aprotic or mixed aqueous/organic solvents, with reaction temperatures selected to preserve sensitive ligands and maintain chemoselectivity.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂