m-PEG11-COOH
CAS No.: 2280998-74-3
Cat No.: BP-501166
Purity: >98%
4.5 
m-PEG11-COOH is a monomethoxy polyethylene glycol linker featuring an ether-rich, flexible PEG segment of intermediate length terminated by a terminal carboxylic acid. The structure provides a hydrophilic, conformationally mobile spacer that can reduce steric interference between a PROTAC’s targeting ligand and its E3 ligase–binding moiety, while the carboxyl group enables straightforward amide-bond formation or other coupling chemistries to attach the linker to activated carboxylates or amine-bearing partners. In targeted protein degradation designs, such PEG spacers are commonly used to tune effective distance and presentation of functional groups, improving the probability of productive ternary complex formation and thereby supporting degradation potency and reproducibility. This product is valuable for constructing modular PROTACs, facilitating rapid synthesis of linker variants, and improving aqueous solubility of conjugates for biochemical and cellular evaluation.
Structure of 2280998-74-3
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m-PEG11-COOH is a polyethylene glycol (PEG)-based carboxylic acid linker designed to support PROTAC assembly by providing a hydrophilic, conformationally flexible spacer between a target-binding ligand and an E3 ligase-recruiting moiety. Its PEG character can improve solubility and reduce nonspecific hydrophobic interactions, which is beneficial for maintaining productive intramolecular proximity during ternary complex formation. The molecule will be described in detail below, including its structural features and practical reactivity for linker-to-ligand conjugation.
Structure: The linker comprises a PEG repeating-unit chain terminated with a carboxylic acid at the aromatic meta position, offering an ether-rich, flexible scaffold. It contains ether linkages along the PEG backbone and a terminal carboxyl group capable of forming amide or ester derivatives under standard coupling conditions.
Reactivity: The carboxylic acid enables PROTAC construction via amide-bond formation with primary amines on ligands or handles using common peptide-coupling strategies. Typical approaches employ carbodiimide or uronium-type coupling reagents with base in polar aprotic solvents, forming an activated carboxyl intermediate that reacts with the nucleophile to yield stable amide linkages. Reaction conditions are generally tuned to preserve ligand integrity and minimize side reactions such as hydrolysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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