Propargyl-PEG4-S-PEG4-acid
CAS No.: 2055041-20-6
Cat No.: BP-501533
Purity: 98%
4.5 
Propargyl-PEG4-S-PEG4-acid is a heterobifunctional, PEG-based linker featuring a terminal propargyl (alkyne) handle for orthogonal conjugation and a thioether-linked PEG spacer that terminates in a carboxylic acid for further coupling to ligands or warheads. Structurally, it comprises two short polyethylene glycol segments connected through a sulfur-containing linkage, providing a flexible, hydrophilic scaffold that can reduce steric constraints and improve solubility of assembled PROTACs. In PROTAC design, the propargyl group enables chemoselective attachment to azide-containing partners or other click-compatible moieties, while the carboxylic acid supports amide or ester formation with complementary functional groups. This linker is therefore useful for constructing modular targeted degradation conjugates in which precise spatial separation between binding elements is required to support productive ternary complex formation and efficient ubiquitin–proteasome pathway engagement.
Structure of 2055041-20-6
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Propargyl-PEG4-S-PEG4-acid is a PEG-based, thioether-containing PROTAC linker designed to connect a propargyl functional handle to a carboxylic acid terminus through flexible polyethylene glycol segments. Its hydrophilic, conformationally adaptable architecture supports efficient conjugation and favorable linker solvation in targeted protein degradation workflows. The molecule is particularly useful for assembling bifunctional degraders where precise spatial presentation of binding motifs and robust synthetic modularity are required. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a propargyl group for chemical “click” reactivity, PEG chains that impart flexibility and water compatibility, a thioether linkage that provides a stable sulfur-containing connection, and a terminal carboxylic acid for coupling. The framework contains ether linkages, a thioether, and an alkyne suitable for bioorthogonal conjugation.
Reactivity: The propargyl alkyne enables copper-catalyzed azide–alkyne cycloaddition with azide-bearing partners under standard click conditions, typically using Cu(I) sources and appropriate stabilizing ligands in aqueous or mixed solvents. The terminal carboxylic acid can be converted to activated esters or acid chlorides for amide or ester bond formation with amine or alcohol nucleophiles. PEG flexibility helps maintain effective reaction kinetics during PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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