Biotin-PEG8-amine
CAS No.: 2183447-27-8
Cat No.: BP-500962
4.5 
Biotin-PEG8-amine is a heterobifunctional PEG-based linker that combines a biotin moiety with an eight-unit polyethylene glycol spacer terminated by a primary amine. The flexible PEG chain provides aqueous solubility and conformational spacing, while the biotin group enables high-affinity binding to streptavidin or avidin, making it a convenient handle for assembling PROTAC-related constructs and for immobilizing or concentrating target-binding components on streptavidin-coated surfaces. The terminal amine serves as a reactive functional group for amide coupling, reductive amination, or other conjugation strategies to attach the linker to electrophiles or activated carboxylic acids present in degraders, ligands, or reporter tags. In targeted protein degradation research, this linker is valuable for designing modular systems where one end must be tethered to a biotin-binding scaffold and the other end must be chemically functionalized, supporting controlled stoichiometry, assay development, and mechanistic studies of ternary-complex formation and cellular uptake.
Structure of 2183447-27-8
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Biotin-PEG8-amine is a PEG-based, biotin-functionalized linker designed to support PROTAC assembly by providing a hydrophilic spacer and a versatile terminal amine for conjugation. Its flexible ether-rich chain helps tune linker length and conformational freedom, which can improve ternary-complex formation and targeted degradation performance. The biotin handle is also commonly leveraged for affinity-based workflows, while the amine enables robust coupling to ligands or warheads. Detailed structural and reactivity guidance is provided below.
Structure: The linker comprises a biotin moiety connected through an ether-rich polyethylene glycol segment to a terminal primary amine. It features multiple ether linkages and amide-compatible functional groups, offering high polarity and aqueous solubility. The flexible PEG backbone provides conformational mobility, while the amine offers a reactive site for further derivatization.
Reactivity: The terminal amine can be used for standard PROTAC linker-ligand conjugation strategies, including amide-bond formation with activated carboxylic acids (such as NHS esters or acid chlorides) and reductive amination with aldehydes or ketones. Coupling is typically performed under mild base or coupling-reagent conditions in appropriate organic/aqueous mixtures, with reaction control to minimize PEG-related side reactions. Purification is commonly guided by affinity or chromatographic methods.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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